Tracer library / [18F]JNJ-46356479

Structure of JNJ-46356479 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 49822116

[18F]JNJ-46356479

Also written as [18F]JNJ-46356479; [F-18]JNJ-46356479

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Radiochemistry methodology

What it is

Compound class: Bpin (boronic acid pinacol ester) precursor-derived organoborane radiotracer
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	—	5 ± 3% not corrected	>95%	compound 4 (Bpin precursor)	33014351 2020 RSC Adv using a computer controlled GE TRACERlab™ FXFN module - The final [18F]JNJ-46356479 was obtained with a radiochemical yield (RCY) of 5 ± 3% (n > 10, non-decay-corrected)

Need this precursor?We can point you to suppliers for [18F]JNJ-46356479, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]JNJ-46356479.

Get in touch

Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 33014351: 'The 18F-fluorodeboronation precursor 4 was synthesized'.