Tracer library / [18F]GE-180
Structure of Flutriciclamide (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 58059361

[18F]GE-180

Also written as [18F]GE-180; [18F]GE180; [F-18]GE-180; [F-18]GE180; F-18 GE-180; F-18 GE180; F-18-GE180
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Clinical research
Syntheses indexed
2
Neuroinflammation

What it is

Compound class
Tricyclic indole
Target / mechanism
TSPO (18 kDa translocator protein) PMID 24448744 / DOI 10.1002/jlcr.3112
Clinical application
Neuroinflammation imaging in CNS disease PMID 24448744 / DOI 10.1002/jlcr.3112
Theranostic pair
—

Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=flutriciclamide
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
Static imaging window ~60-90 min post-injection used in practice; first-in-human study used a 210-min dynamic scan for kinetic modelling PMID 36906584 / DOI 10.1186/s12974-023-02749-2; PMID 27261523 / DOI 10.2967/jnumed.115.169078

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
—SPE69 ± 1.8%
not corrected
——35349890
2022 Appl Radiat Isot
The nucleophilic radiofluorination was performed on an AllinOne synthesis module by SPE purification method - non-decay corrected radiochemical yields of 69 ± 1.8% in 32 min
FASTlab
GE HealthCare
—SPE48%
not corrected
≥95%S-enantiomer mesylate precursor24448744
2014 J Labelled Comp Radiopharm
An optimized, automated synthesis of [(18) F]GE-180 has been developed for the GE FASTlab™ synthesizer. - The average radiochemical yield is 48% (RSD 6%, non-decay corrected)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Targeting Chemokine Receptor CXCR4 and Translocator Protein for Characterization of High-Risk Plaque in Carotid Stenosis Ex Vivo.
    2018 · Stroke · Clinical study

Precursor

Common precursor
S-enantiomer mesylate precursor (nucleophilic [18F]fluorination) PMID 24448744 / DOI 10.1002/jlcr.3112
Suppliers seen in the literature
—
Typical final purification
SPE

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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