Tracers / [18F]GE-180
[18F]GE-180
Also written as [18F]GE-180; [18F]GE180; [F-18]GE-180; [F-18]GE180; F-18 GE-180; F-18 GE180; F-18-GE180
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Clinical research
- Syntheses indexed
- 3
What it is
- Compound class
- Tricyclic indole
- Target / mechanism
- TSPO (18 kDa translocator protein) PMID 24448744 / DOI 10.1002/jlcr.3112
- Clinical application
- Neuroinflammation imaging in CNS disease PMID 24448744 / DOI 10.1002/jlcr.3112
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=flutriciclamide
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- Static imaging window ~60-90 min post-injection used in practice; first-in-human study used a 210-min dynamic scan for kinetic modelling PMID 36906584 / DOI 10.1186/s12974-023-02749-2; PMID 27261523 / DOI 10.2967/jnumed.115.169078
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | SPE | 69 ± 1.8% no | — | — | 35349890 2022 Appl Radiat Isot The nucleophilic radiofluorination was performed on an AllinOne synthesis module by SPE purification method — non-decay corrected radiochemical yields of 69 ± 1.8% in 32 min |
| — | — | — | — | — | — | 30002148 2018 Stroke |
| — | — | SPE | 48% no | ≥95% | S-enantiomer mesylate precursor | 24448744 2014 J Labelled Comp Radiopharm An optimized, automated synthesis of [(18) F]GE-180 has been developed for the GE FASTlab™ synthesizer. — The average radiochemical yield is 48% (RSD 6%, non-decay corrected) |
Precursor
- Common precursor
- S-enantiomer mesylate precursor (nucleophilic [18F]fluorination) PMID 24448744 / DOI 10.1002/jlcr.3112
- Suppliers seen in the literature
- —
- Typical final purification
- SPE
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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