Tracer library / 16-[18F]fluoro-4-thia-palmitic acid
16-[18F]fluoro-4-thia-palmitic acid
Also written as 16-[18F]fluoro-4-thia-palmitic acid
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 3
What it is
- Compound class
- fluorothia fatty acid (16-fluoro-4-thia-palmitic acid, a thia-substituted fatty acid analog)
- Target / mechanism
- —
- Clinical application
- myocardial fatty acid metabolism imaging for clinical applications (as a fatty acid analog tracer) PMID 31759313
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| In-house / custom built | custom manifold | SPE | 37.73% decay-corrected | >96% | N-Boc-Tosylpropoxytryptophan methyl ester | 25136592 2014 Biomed Res Int We have designed and built an automated module which is compact and easy to use and be maintained. - The radioactivity, radiochemical yield, and end-of-synthesis (EOS) time for 18F-FTP were 0.13 GBq, 37.73% (decay-corrected), and 90 min, respectively. |
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 11 ± 2 decay-corrected | >97% | mesylate precursor of FTP made in our lab under GLP conditions | 29564391 2017 EJNMMI Radiopharm Chem AllinOne synthesis module - [18F]FTP1211 ± 22500–468060One vessel, one step, HPLC, SPE |
| TRACERlab FX N Pro | — | HPLC+SPE | 7.7±4.5 % not corrected | 95.8% | methyl 3-(12-bromododecylthio)propionate | 31759313 2020 Nucl Med Biol All the syntheses were optimized in an automated TRACERlab FX-N Pro synthesizer. - [18F]FTP uncorrected yield was 7.7±4.5 % |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- made in our lab under GLP conditions
- Typical final purification
- —
Need this precursor?We can point you to suppliers for 16-[18F]fluoro-4-thia-palmitic acid, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release 16-[18F]fluoro-4-thia-palmitic acid.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Stage set/updated at stage 39 from PMID 31759313: 'were used as precursors for the synthesis of [18F]FTHA and [18F]FTP, respectively'.