Tracer library / [18F]F-PRGD2

[18F]F-PRGD2

Also written as [18F]F-PRGD2; [F-18]F-PRGD2

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 3

Angiogenesis

What it is

Compound class: Dimeric RGD-peptide (PEG3-c(RGDyK)2 scaffold)
Target / mechanism: αvβ3 integrin expression PMID 21400112
Clinical application: PET imaging of αvβ3 integrin expression for detecting and monitoring tumor growth and metastasis PMID 21400112
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	custom manifold	HPLC+SPE	16.9±2.7% decay-corrected	>99%	PEG3-c(RGDyK)2 Peptides International Inc.	21400112 2012 Mol Imaging Biol a modified commercial radiosynthesis module (TRACERlab FXFN, GE Medical Systems) and a custommade module - [18F]FPP(RGD)2 was afforded with consistent RCYs (16.9±2.7%; n=8)
iPHASE FlexLab iPHASE Technologies	—	—	~4% not corrected	—	PRGD2	29143364 2018 J Labelled Comp Radiopharm use of the iPHASE Flexlab as an effective dual-stage radiochemical synthesis module - n.d.c. yields ca. 4% from fluoride
FASTlab GE HealthCare	—	—	13% ± 3% decay-corrected	>98%	—	21267662 2011 Mol Imaging Biol GE FASTlab™ synthesizer - d.c. yield of 13% ± 3% (n = 13) in 130 min

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Peptides International Inc.
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 21400112: 'H-11-amino-3,6,9-trioxaundecanoic acid (AEEEA)-Glu[cyclo(Arg-Gly-Asp-d-Tyr-Lys)]2 (PEG3-c(RGDyK)2) (AEEEA, 99%), was purchased from Peptides International (USA).'. Stage set/updated at stage 23 from PMID 21400112: 'Imaging studies with [¹⁸F]FPP(RGD)₂ in normal mice and a healthy human volunteer were carried out using small animal and clinical PET scanners, respectively.'. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.