Tracers / [18F]F-PRGD2
[18F]F-PRGD2
Also written as [18F]F-PRGD2; [F-18]F-PRGD2
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 3
What it is
- Compound class
- Dimeric RGD-peptide (PEG3-c(RGDyK)2 scaffold)
- Target / mechanism
- αvβ3 integrin expression PMID 21400112
- Clinical application
- PET imaging of αvβ3 integrin expression for detecting and monitoring tumor growth and metastasis PMID 21400112
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN GE HealthCare | custom manifold | HPLC+SPE | 16.9±2.7% yes | >99% | PEG3-c(RGDyK)2 Peptides International Inc. | 21400112 2012 Mol Imaging Biol a modified commercial radiosynthesis module (TRACERlab FXFN, GE Medical Systems) and a custommade module — [18F]FPP(RGD)2 was afforded with consistent RCYs (16.9±2.7%; n=8) |
| — | — | — | ca. 4% no | — | PRGD2 | 29143364 2018 J Labelled Comp Radiopharm use of the iPHASE Flexlab as an effective dual-stage radiochemical synthesis module — n.d.c. yields ca. 4% from fluoride |
| — | — | — | 13% ± 3% yes | >98% | — | 21267662 2011 Mol Imaging Biol GE FASTlab™ synthesizer — d.c. yield of 13% ± 3% (n = 13) in 130 min |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]F-PRGD2.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 21400112: 'H-11-amino-3,6,9-trioxaundecanoic acid (AEEEA)-Glu[cyclo(Arg-Gly-Asp-d-Tyr-Lys)]2 (PEG3-c(RGDyK)2) (AEEEA, 99%), was purchased from Peptides International (USA).'. Stage set/updated at stage 23 from PMID 21400112: 'Imaging studies with [¹⁸F]FPP(RGD)₂ in normal mice and a healthy human volunteer were carried out using small animal and clinical PET scanners, respectively.'.