[18F]FP-(+)-DTBZ

Also written as [18F]FP-(+)-DTBZ

Radionuclide: F-18
Modality: —
Production route: —
Stage: —
Syntheses indexed: 5

Parkinsonian syndromes and movement disorders

What it is

Compound class: Dihydrotetrabenazine derivative (VMAT2 tracer)
Target / mechanism: Vesicular monoamine transporter 2 (VMAT2) PMID 31165386
Clinical application: Parkinson's disease imaging PMID 34307421
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
CFN-MPS200	—	SPE	29 ± 1.8%	99.0%	TsOP-(+)-DTBZ College of Chemistry, Jilin University	34307421 2021 Front Med (Lausanne) 18F was passed into the CFN-MPS200 multi-functional synthesis module through the target transmission system — radiochemical yield of 29 ± 1.8% with radiochemical purity >99% and shortened synthesis time to 27 min
CFN-MPS200	—	HPLC	11 ± 2.3%	99.2%	TsOP-(+)-DTBZ College of Chemistry, Jilin University	34307421 2021 Front Med (Lausanne) 18F was passed into the CFN-MPS200 multi-functional synthesis module through the target transmission system — Yield rate11 ± 2.3%25 ± 2.327 ± 2.129 ± 1.8 %
CFN-MPS200	—	SPE	25 ± 2.3%	98.5%	TsOP-(+)-DTBZ College of Chemistry, Jilin University	34307421 2021 Front Med (Lausanne) 18F was passed into the CFN-MPS200 multi-functional synthesis module through the target transmission system — Yield rate11 ± 2.3%25 ± 2.327 ± 2.129 ± 1.8 %
CFN-MPS200	—	SPE	27 ± 2.1%	98.0%	TsOP-(+)-DTBZ College of Chemistry, Jilin University	34307421 2021 Front Med (Lausanne) 18F was passed into the CFN-MPS200 multi-functional synthesis module through the target transmission system — Yield rate11 ± 2.3%25 ± 2.327 ± 2.129 ± 1.8 %
—	—	SPE	30-55%	>99.0%	—	31165386 2020 Mol Imaging Biol successfully applied it to a commercial available module — gave a high activity yield (AY) of 30-55 % in about 40 min

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: College of Chemistry
Typical final purification: —

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Notes

Added at stage 39 (2026-09-27) from a reverse search of the PubMed corpus's own unattached articles (articles that named a real compound not yet in this reference): 2 article(s) found under this name, not yet individually researched. Target/mechanism, clinical application, indications, approval, modality, stage and production route are intentionally left empty. PMIDs: 31165386, 34307421.