Tracer library / [18F]FP-CIT
Structure of FP-CIT (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 10048368

[18F]FP-CIT

Also written as [18F]FP-CIT; [F-18]FP-CIT; F-18 FP-CIT; FP-CIT
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Parkinsonian syndromes and movement disordersCNS receptor and transporter imaging

What it is

Compound class
Dopamine transporter (DAT) ligand (nortropane derivative)
Target / mechanism
Dopamine transporter (DAT) - striatal dopaminergic terminal density PMID 34414983
Clinical application
Dopamine transporter imaging in Parkinson's disease for assessment of nigrostriatal dopaminergic degeneration PMID 32134983
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
TRACERlab FX (model not stated)
GE HealthCare
—HPLC42.5±10.9%
decay-corrected
——21531297
2011 Nucl Med Biol
applied these conditions to automatic preparation with GE TracerLab FX module - We have 42.5±10.9% of decay corrected radiochemical yields

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Intrasubject relationship between striatal 18F-FP-CIT uptake and cardiac 123I-MIBG uptake differs by motor subtype in early Parkinson disease.
    2021 · Medicine (Baltimore) · Retrospective
  2. Gastric emptying time and its correlation with cardiac MIBG in body-first and brain-first subtype Parkinson's disease.
    2024 · J Neurol · Clinical study
  3. Association of plasma α-synuclein with cardiac 123I-MIBG scintigraphy in early Parkinson's disease.
    2022 · Neurosci Lett · Clinical study
  4. Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson's disease.
    2020 · PLoS One · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.
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