Tracers / [18F]FP-CIT

[18F]FP-CIT

Also written as [18F]FP-CIT; [F-18]FP-CIT; F-18 FP-CIT; FP-CIT
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
3
Parkinsonian syndromes and movement disordersCNS receptor and transporter imaging

What it is

Compound class
Dopamine transporter (DAT) ligand (nortropane derivative)
Target / mechanism
Dopamine transporter (DAT) - striatal dopaminergic terminal density PMID 34414983
Clinical application
Dopamine transporter imaging in Parkinson's disease for assessment of nigrostriatal dopaminergic degeneration PMID 32134983
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
——————34414983
2021 Medicine (Baltimore)
——————32134983
2020 PLoS One
——HPLC42.5±10.9%
yes
——21531297
2011 Nucl Med Biol
applied these conditions to automatic preparation with GE TracerLab FX module — We have 42.5±10.9% of decay corrected radiochemical yields

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.