Tracer library / [18F]FMZ
[18F]FMZ
Also written as [18F]Flumazenil; [18F]FMZ; [F-18]Flumazenil; [F-18]FMZ; Flumazenil
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- Radiolabelled imidazobenzodiazepine (flumazenil derivative)
- Target / mechanism
- Central benzodiazepine site of the GABA-A receptor PMID 23857513
- Clinical application
- Localisation of the epileptogenic zone in drug-resistant temporal lobe epilepsy (presurgical evaluation) PMID 23857513
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| iPHASE FlexLab iPHASE Technologies | — | HPLC+SPE | 22.2 ± 2.7% decay-corrected | >98% | stannyl precursor 3 (Ethyl…stannyl precursor 3 (Ethyl 5-methyl-6-oxo-8-(tributylstannyl)-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate) In-house / non-commercial (various) | 36144667 2022 Molecules the iPHASE Flexlab radiochemistry module - affording a 22.2 ± 2.7% (n = 5) decay-corrected yield after 80 min |
| AllinOne (AiO) Trasis | vendor cassette | HPLC | 35 ± 5% not corrected | 18 [ F]flumazenil > 99% | FMZ-BPin In-house / non-commercial (various) | 35306596 2022 EJNMMI Radiopharm Chem The fully automated synthesis was developed on the Trasis AllinOne (AIO) platform using a single-use cassette. - this method yielded [18F]FMZ in 35 ± 5% n.d.c. |
| AllinOne (AiO) Trasis | vendor cassette | HPLC | 43 ± 2% not corrected | 18 [ F]flumazenil ≥ 98% | FMZ-BPin In-house / non-commercial (various) | 35306596 2022 EJNMMI Radiopharm Chem The fully automated synthesis was developed on the Trasis AllinOne (AIO) platform using a single-use cassette. - Starting with 300–340 MBq (n = 5, Trasis) of [18F]fluoride this method yielded [18F]FMZ in 43 ± 2% n.d.c. |
| TRACERlab FX FN GE HealthCare | — | HPLC+SPE | 15-20 decay-corrected | >95% | nitroflumazenil | 36986516 2023 Pharmaceuticals (Basel) All synthesis and purification procedures were performed on a Tracerlab FX-FN automated synthesizer - with a radiochemical yield (RCY) of 15–20% decay, corrected at the end of bombardment (EOB) |
| In-house / custom built Laboratory | — | — | 20% for [18F]flumazenil | — | — | 22001413 2012 Appl Radiat Isot The substitutions were carried out in a microfluidic reaction flow cell - 20% for [(18)F]flumazenil |
| TRACERlab FX N Pro GE HealthCare | — | SPE | 6.4 ± 0.7% not corrected | >97% | — | 29413823 2018 Appl Radiat Isot All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min. - FMZ was routinely synthesized in 6.4 ± 0.7% RCY at EOS (not decay corrected, n = 8) |
| In-house / custom built Laboratory | — | SPE | 26±4% | >99% | nitro-flumazenil precursor | 19423008 2009 Nucl Med Biol an automated radiosynthesis system integrating a microwave reactor - The radiochemical yield obtained at the end of synthesis was 26+/-4% (EOB) |
Precursor
- Common precursor
- 2-nitroflumazenil PMID 27090254 (DOI 10.1186/s13550-016-0168-9)
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- In-house / non-commercial (various)
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FMZ.
Get in touchNotes
Added from reverse module search (stage 6); 8 article(s) with F-18.