Tracer library / [18F]FMN3PU

[18F]FMN3PU

Also written as [18F]FMN3PU; [F-18]FMN3PU

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Parkinsonian syndromes and movement disorders

What it is

Compound class: radiolabeled kinase inhibitor (fluorinated urea-based LRRK2 PET tracer)
Target / mechanism: leucine-rich repeat kinase 2 (LRRK2) PMID 33248850
Clinical application: Parkinson's disease (G2019S LRRK2 mutation, late-onset) PMID 33248850
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX N GE HealthCare	—	SPE	25 ± 1.3%	≥96%	—	33248850 2021 Eur J Med Chem Radiosyntheses of [18F]FMN3PA (14) and [18F]FMN3PU (15) were performed using K[18F]-F-K222 complex in a TRACERlab FXN module - 25 ± 1.3% (n = 6) ([18F]FMN3PU, 15)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.