Tracer library / [18F]FMeNER-D2

[18F]FMeNER-D2

Also written as [18F]FMeNER-D2; [F-18]FMeNER-D2

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

CNS receptor and transporter imaging ADHD and neurodevelopmental disorders

What it is

Compound class: (S,S)-norethyl-reboxetine derivative (morpholine-based NET ligand)
Target / mechanism: Norepinephrine transporter (NET) PMID 24100201
Clinical application: PET imaging of norepinephrine transporter availability and occupancy in human brain, applied to healthy volunteers and ADHD patients PMID 24100201
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Nuclear Interface GE HealthCare	fixed tubing	HPLC+SPE	12.0% ± 5.2% not corrected	≥98%	(S,S)-NER PharmaSynth AS, Tartu, Estonia	24100201 2013 Nucl Med Biol [18F]FMeNER-D2 synthesis was automated within a Nuclear Interface synthesizer (GE Healthcare, Sweden), remotely controlled by a standard laptop with dedicated processing software - yielding 1.53 ± 0.6 GBq [18F]FMeNER-D2 (12.0% ± 5.2%, not corrected for decay) within 100 min from the end of bombardment
—	—	—	9.0%	>97%	norethylreboxetine (NER)	40814241 2025 J Labelled Comp Radiopharm [18F]FMeNER-D2 synthesized using an 18F-labeling synthesizer equipped with a one-pot unit - 9.0% ± 0.8% (n = 3)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: PharmaSynth AS
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 24100201: 'Precursor (S,S)-NER (=(S,S)-norethyl-reboxetine, =(2S, 3S)-2-[α-(2-hydroxyphenoxy) benzyl]morpholine) and reference standard (S,S)-FMeNER-D2*TFA'. | Stage 28: added indication(s) psy-adhd from consolidated missing-rubric review.