Tracers / [18F]FMeNER-D2
[18F]FMeNER-D2
Also written as [18F]FMeNER-D2; [F-18]FMeNER-D2
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
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- Syntheses indexed
- 3
What it is
- Compound class
- (S,S)-norethyl-reboxetine derivative (morpholine-based NET ligand)
- Target / mechanism
- Norepinephrine transporter (NET) PMID 24100201
- Clinical application
- PET imaging of norepinephrine transporter availability and occupancy in human brain, applied to healthy volunteers and ADHD patients PMID 24100201
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
- —
Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Nuclear Interface GE HealthCare | fixed tubing | HPLC+SPE | 12.0% ± 5.2% no | ≥98% | (S,S)-NER PharmaSynth AS, Tartu, Estonia | 24100201 2013 Nucl Med Biol [18F]FMeNER-D2 synthesis was automated within a Nuclear Interface synthesizer (GE Healthcare, Sweden), remotely controlled by a standard laptop with dedicated processing software — yielding 1.53 ± 0.6 GBq [18F]FMeNER-D2 (12.0% ± 5.2%, not corrected for decay) within 100 min from the end of bombardment |
| — | — | — | — | — | desfluoromethoxy-(S,S)-FMeNER | 32274584 2020 J Neural Transm (Vienna) |
| — | — | — | 9.0% | >97% | norethylreboxetine (NER) | 40814241 2025 J Labelled Comp Radiopharm [18F]FMeNER-D2 synthesized using an 18F-labeling synthesizer equipped with a one-pot unit — 9.0% ± 0.8% (n = 3) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FMeNER-D2.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 24100201: 'Precursor (S,S)-NER (=(S,S)-norethyl-reboxetine, =(2S, 3S)-2-[α-(2-hydroxyphenoxy) benzyl]morpholine) and reference standard (S,S)-FMeNER-D2*TFA'. | Stage 28: added indication(s) psy-adhd from consolidated missing-rubric review.