Tracer library / [18F]fluorosulfate

Structure of fluorosulfate (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 3413884

[18F]fluorosulfate

Also written as [18F]fluorosulfate; [F-18]fluorosulfate

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 0

Thyroid function and NIS expression

What it is

Compound class: aryl fluorosulfate / SuFEx-based small molecule PET tracer
Target / mechanism: human sodium-iodide symporter (hNIS) PMID 27539841
Clinical application: thyroid-related disease PMID 27539841
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.