Tracers / [18F]fluorosulfate
[18F]fluorosulfate
Also written as [18F]fluorosulfate; [F-18]fluorosulfate
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- aryl fluorosulfate / SuFEx-based small molecule PET tracer
- Target / mechanism
- human sodium-iodide symporter (hNIS) PMID 27539841
- Clinical application
- thyroid-related disease PMID 27539841
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | aryl imidazylate | 32589035 2020 Org Lett |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluorosulfate.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.