Tracers / [18F]fluorocellobiose
[18F]fluorocellobiose
Also written as [18F]Fluorocellobiose; [F-18]Fluorocellobiose
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- Fluorine-18-labeled disaccharide (2-deoxy-2-[18F]fluoro analog of cellobiose)
- Target / mechanism
- β-glucosidase-mediated hydrolysis of fluorocellobiose to [18F]FDG by cellulolytic fungal metabolism PMID 39141701
- Clinical application
- Invasive fungal infections (e.g., Aspergillus) in immunocompromised patients PMID 39141701
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | SPE | 50-70% yes | >98% | 2-deoxy-2-[18F]fluoroglucose ([18F]FDG), glucose-1-phosphate, and enzyme (cellobiose phosphorylase) | 38982015 2024 J Labelled Comp Radiopharm Trasis AllInOne (Trasis AIO) automated module was used for this purpose — The overall radiochemical yield was 50%-70% (n = 6, decay corrected) in 75-min synthesis time |
Need this precursor?We can point you to suppliers for [18F]fluorocellobiose, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluorocellobiose.
Get in touchNotes
Added from reverse module search (stage 6); 5 article(s) with F-18.