Tracers / [18F]Fluciclatide
[18F]Fluciclatide
Also written as [18F]AH111585; [18F]Fluciclatide; [F-18]AH111585; [F-18]Fluciclatide; AH111585; F-18 AH111585; F-18 Fluciclatide
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 0
What it is
- Compound class
- Peptide (RGD)
- Target / mechanism
- Integrin alpha-v beta-3 (RGD peptide); marker of angiogenesis PMID 19719118 / DOI 10.1021/bc900167c
- Clinical application
- Imaging of angiogenesis / integrin alpha-v beta-3 expression; response to antiangiogenic therapy PMID 26383153 / DOI 10.2967/jnumed.115.158253
- Theranostic pair
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Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluciclatide
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- Target dose ~230 MBq (229 +/- 12 MBq); other studies up to 370 MBq PMID 27927700 / DOI 10.1136/heartjnl-2016-310115; PMID 26383153 / DOI 10.2967/jnumed.115.158253
- Uptake time
- Static imaging ~40 min post-injection (dynamic/patient scans acquired 40-90 min p.i.) PMID 27927700 / DOI 10.1136/heartjnl-2016-310115; PMID 26383153 / DOI 10.2967/jnumed.115.158253
Reported in the literature. Not a dosing recommendation.
Published syntheses
No synthesis has been parsed for this agent yet.
Precursor
- Common precursor
- Amino-oxy-functionalised cyclic-RGD peptide precursor AH111695, coupled with 4-[18F]fluorobenzaldehyde at pH 3.5 PMID 27927700 / DOI 10.1136/heartjnl-2016-310115
- Suppliers seen in the literature
- —
- Typical final purification
- SPE
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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