Tracer library / [18F]FEPPA
Structure of FEPPA (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 74341292

[18F]FEPPA

Also written as [18F]FEPPA; [F-18]FEPPA; FEPPA
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
Neuroinflammation

What it is

Compound class
Radiolabelled phenoxyphenyl acetamide (second-generation TSPO ligand)
Target / mechanism
18-kDa translocator protein (TSPO), microglial-activation marker PMID 23350894
Clinical application
Neuroinflammation imaging via TSPO expression in activated microglia PMID 33725191
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Modular-Lab (model not stated)
Eckert & Ziegler
custom manifoldHPLC+SPE30 ± 2%
not corrected
>99%tosylated precursor…tosylated precursor (2-(2-((N-4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl 4-methylbenzenesulfonate)
Huayi
33725191
2021 EJNMMI Res
Radiosynthesis was performed using an Eckert-Ziegler modular system (Eckert-Ziegler, Berlin, Germany) - The overall production of [18F]FEPPA was 30 ± 2% (decay-uncorrected, n = 8).
———29%
not corrected
>99%—31083778
2019 J Labelled Comp Radiopharm
synthesized and formulated using an automated radiosynthesis module - nondecay corrected radiochemical yields of 27% and 29% (relative [18 F]F- ), respectively

Precursor

Common precursor
—
Suppliers seen in the literature
—
Cited suppliers in indexed syntheses
Huayi
Typical final purification
—

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18.
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