Tracers / [18F]FEPPA
[18F]FEPPA
Also written as [18F]FEPPA; [F-18]FEPPA; FEPPA
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- Radiolabelled phenoxyphenyl acetamide (second-generation TSPO ligand)
- Target / mechanism
- 18-kDa translocator protein (TSPO), microglial-activation marker PMID 23350894
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab (model not stated) Eckert & Ziegler | custom manifold | HPLC+SPE | 30 ± 2% no | >99% | tosylated precursor (2-(2-((N-4-phenoxypyridin-3-yl)acetamido)methyl)phenoxy)ethyl 4-methylbenzenesulfonate) Huayi | 33725191 2021 EJNMMI Res Radiosynthesis was performed using an Eckert-Ziegler modular system (Eckert-Ziegler, Berlin, Germany) — The overall production of [18F]FEPPA was 30 ± 2% (decay-uncorrected, n = 8). |
| — | — | — | — | — | — | 29541356 2018 ACS Med Chem Lett |
| — | — | — | 29% no | >99% | — | 31083778 2019 J Labelled Comp Radiopharm synthesized and formulated using an automated radiosynthesis module — nondecay corrected radiochemical yields of 27% and 29% (relative [18 F]F- ), respectively |
| — | — | — | 30%±8% no | — | — | 23350894 2013 Cancer Biother Radiopharm An automated radiosynthesis of [(18)F]-N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([(18)F]FEPPA) was validated for human use using a commercial synthesis module — resulted in a high radiochemical yield (30%±8%, uncorrected; n=54) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FEPPA.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18.