Tracers / [18F]FAPI-42

[18F]FAPI-42

Also written as [18F]FAPI-42; [F-18]FAPI-42

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 3

Fibrosis (non-oncologic)Autoimmune / immune-mediated systemic disease

What it is

Compound class: NOTA-FAPI-04 (fibroblast activation protein inhibitor, NOTA-conjugated small molecule)
Target / mechanism: Fibroblast activation protein (FAP) inhibitor targeting FAP-expressing cells PMID 41781161
Clinical application: PET/CT imaging for detection and activity scoring of IgG4-related disease PMID 41781161
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	—	—	—	42635770 2026 Eur J Nucl Med Mol Imaging
—	—	—	—	—	—	40923896 2025 Mol Pharm
—	—	—	—	—	—	40345824 2025 J Nucl Med Technol

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 4 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 41781161: 'the FAPI-04 precursor, 1,4,7-triazacyclononane-N, N', N"-triacetic acid (NOTA) FAPI-04, was obtained from Beijing PET Technology (Beijing, China).'. | Stage 28: added indication(s) inf-autoimmune from consolidated missing-rubric review.