Tracer library / [18F]DPA-C5yne

[18F]DPA-C5yne

Also written as [18F]DPA-C5yne; [F-18]DPA-C5yne

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Neuroinflammation

What it is

Compound class: pyrazolo[1,5-a]pyrimidine acetamide (DPA-714 fluoroalkynyl analogue)
Target / mechanism: translocator protein 18 kDa (TSPO) PMID 24764161
Clinical application: neuroinflammation imaging (preclinical rat model of acute local neuroinflammation) PMID 24764161
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX N Pro GE HealthCare	—	HPLC+SPE	14-17%	>95%	—	24764161 2014 J Labelled Comp Radiopharm formulated as an i.v. injectable solution using a TRACERLab FX N Pro synthesizer - starting from a 30 GBq [(18)F]fluoride batch (14-17%)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.