Tracer library / [18F]DK222

[18F]DK222

Also written as [18F]DK222; [F-18]DK222; DK222

Radionuclide: F-18 t½ 109.7 min
Modality: PET
Production route: Cyclotron liquid target
Stage: Research
Syntheses indexed: 2

Receptor expression phenotyping Immune cell and immunotherapy imaging Lung cancer Melanoma

What it is

Compound class: Cyclic peptide binder (NODA/NOTA-type chelator conjugated macrocyclic peptide)
Target / mechanism: Programmed death-ligand 1 (PD-L1); peptide binder PMID 36627757 / DOI 10.1002/jlcr.4012
Clinical application: PET imaging of PD-L1 expression in cancer and of pharmacodynamic changes during PD-1/PD-L1 immunotherapy (NSCLC, urothelial carcinoma, melanoma models); cGMP radiosynthesis validated for human PET PMID 36627757 / DOI 10.1002/jlcr.4012; PMID 37793856 / DOI 10.1136/jitc-2023-007535
Theranostic pair: —

Regulatory status

FDA: No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=DK222
EMA (centralised): —
Other approvals: —
Brand names: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built in-house	custom manifold	SPE	52.2% ± 3.6% not corrected	—	DK-NODA CPC Scientific, San Jose, CA	36627757 2023 J Labelled Comp Radiopharm The vial was then connected to a custom-built solid phase extraction (SPE) module for purification and formulation (see supplemental data). - resulting in a non-decay corrected radiochemical yield of 52.2% ± 3.6%
FASTlab 2 GE HealthCare	vendor cassette	SPE	30.0% ± 4.6% not corrected	—	DK-NODA CPC Scientific, San Jose, CA	36627757 2023 J Labelled Comp Radiopharm the GE FastLab2 synthesis module using the GE FastLab developer software version 3.2.0.2 - The non-decay corrected yield of [18F]DK222 was 30.0% ± 4.6%

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: CPC Scientific
Typical final purification: SPE

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Target and application not filled - to be taken from the publication. Compound class inferred from precursor name (not stated outright) -- PMID 36627757: 'cyclo-(Ac-Tyr-NMeAla-Asn-Pro-His-Glu-Hyp-Trp-Ser-Trp(Carboxymethyl)-NMeNle-NMeNle-Lys(NODA_NCS)-Cys-)-Gly-NH2; known hereafter as simply DK-NODA'.