Tracer library / [18F]DAA1106

Structure of DAA1106 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 10430788

[18F]DAA1106

Also written as [18F]DAA1106; [F-18]DAA1106

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 4

Neuroinflammation Radiochemistry methodology Substance use disorders / addiction

What it is

Compound class: N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide, a TSPO ligand
Target / mechanism: translocator protein (18 kDa, TSPO) PMID 30166255
Clinical application: Ischemic stroke / cerebral ischemia with neuroinflammation PMID 30166255
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	HPLC	6%	>98%	spirocyclic iodonium ylide (1)	30166255 2018 Bioorg Med Chem
Scintomics HotBox III Scintomics	—	—	41-61%	>95%	—	27372807 2016 Appl Radiat Isot commercially available synthesis module (hotbox(three), Scintomics, Germany) - radiochemical yields of 41-61%
Nuclear Interface Nuclear Interface (legacy)	—	—	≤25%	99%	DAA1123	17499734 2007 Nucl Med Biol implemented on a nuclear interface methylation module - producing [(11)C]DAA1106 with up to 25% radiochemical yields at end-of-synthesis based on [(11)C]CH(3)I trapped
Nuclear Interface Nuclear Interface (legacy)	—	—	—	99%	DAA1123	17499734 2007 Nucl Med Biol implemented on a nuclear interface methylation module

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18. Also seen with C-11[1] (too few articles for own row). | Stage 28: added indication(s) psy-addiction from consolidated missing-rubric review.