Tracers / [18F]DAA1106
[18F]DAA1106
Also written as [18F]DAA1106; [F-18]DAA1106
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 5
What it is
- Compound class
- N-(2,5-dimethoxybenzyl)-N-(5-fluoro-2-phenoxyphenyl)acetamide, a TSPO ligand
- Target / mechanism
- translocator protein (18 kDa, TSPO) PMID 30166255
- Clinical application
- Ischemic stroke / cerebral ischemia with neuroinflammation PMID 30166255
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 27943464 2017 Chemistry |
| — | — | HPLC | 6% | >98% | spirocyclic iodonium ylide (1) | 30166255 2018 Bioorg Med Chem |
| — | — | — | 41-61% | >95% | — | 27372807 2016 Appl Radiat Isot commercially available synthesis module (hotbox(three), Scintomics, Germany) — radiochemical yields of 41-61% |
| — | — | — | up to 25% | 99% | DAA1123 | 17499734 2007 Nucl Med Biol implemented on a nuclear interface methylation module — producing [(11)C]DAA1106 with up to 25% radiochemical yields at end-of-synthesis based on [(11)C]CH(3)I trapped |
| — | — | — | — | 99% | DAA1123 | 17499734 2007 Nucl Med Biol implemented on a nuclear interface methylation module |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]DAA1106.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Also seen with C-11[1] (too few articles for own row). | Stage 28: added indication(s) psy-addiction from consolidated missing-rubric review.