Tracer library / [18F]cGBP4F

[18F]cGBP4F

Also written as [18F]cGBP4F; [F-18]cGBP4F

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

CNS receptor and transporter imaging

What it is

Compound class: Radiofluorinated gabapentin derivative
Target / mechanism: Ligand for the α2δ subunit of voltage-dependent calcium channels PMID 37732236
Clinical application: Brain PET imaging of α2δ receptors; potential relevance to neuropathic pain and epilepsy PMID 37732236
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX2 N GE HealthCare	—	HPLC	1.4 ± 1.2 not corrected	>99%	precursor 1b	37947793 2023 ACS Chem Neurosci automated radiosynthesis methods were developed using a GE TRACERlab FX2N two-reactor synthesis module - non-decay corrected radiochemical yield: 1.4 ± 1.2 %, n = 3
TRACERlab FX2 N GE HealthCare	—	HPLC	1.4 ± 1.2 % not corrected	>99%	isomerically pure precursor 1b	37732236 2023 bioRxiv automated radiosynthesis methods were developed using a GE TRACERlab FX2N two-reactor synthesis module - non-decay corrected radiochemical yield: 1.4 ± 1.2 %, n = 3

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.