Tracer library / [18F]AlF-NOTA-RD2

[18F]AlF-NOTA-RD2

Also written as [18F]AlF-NOTA-RD2; [F-18]AlF-NOTA-RD2

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Hepatobiliary and pancreatic cancer Receptor expression phenotyping

What it is

Compound class: Peptide (NOTA-conjugated integrin α6-targeted peptide, RD2)
Target / mechanism: Integrin α6 PMID 37463487
Clinical application: Pancreatic cancer imaging PMID 37463487
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
FASTlab 2 GE HealthCare	—	—	23.7 ± 4.7%	>99%	NOTA-RD2	37463487 2023 Mol Pharm produced using GMP (Good Manufacturing Practice of Medical Products)-compliant automatic radiosynthesis on a single GE FASTLab2 cassette-type synthesis module - radiochemical yield of 23.7 ± 4.7%

Need this precursor?We can point you to suppliers for [18F]AlF-NOTA-RD2, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]AlF-NOTA-RD2.

Get in touch

Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 37463487: 'NOTA-RD2'. Stage set/updated at stage 39 from PMID 37463487: 'small-animal PET imaging and biodistribution studies of [18F]-AlF-NOTA-RD2 were performed in pancreatic cancer subcutaneous tumor-bearing mice'.