Tracer library / [18F]AlF

[18F]AlF

Also written as [18F]AlF; [18F]AlF2+; [F-18]AlF; [F-18]AlF2+; AlF; F-18 AlF
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
0
Lung cancerAngiogenesisReceptor expression phenotyping

What it is

Compound class
RGD peptide, NOTA-conjugated (NOTA-PRGD2), labeled via Al18F
Target / mechanism
Integrin αvβ3 PMID 23554506
Clinical application
PET imaging of integrin αvβ3 expression in lung cancer patients for angiogenesis assessment PMID 23554506
Theranostic pair
—

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Clinical Evaluation of [18F]AlF-NOTA-GL01 PET/CT in patients with solid tumors: a prospective comparison with [18F]FDG and an exploratory [18F]FAPI-42 subset.
    2026 · Eur J Nucl Med Mol Imaging · Prospective
  2. Assessment of liver fibrosis and tumor burden in hepatocellular carcinoma using [18F]AlF-NOTA-FAPI-04 PET/CT: a prospective study.
    2026 · Eur J Nucl Med Mol Imaging · Prospective
  3. Molecular imaging of fibroblast activation in systemic sclerosis using [18F]AlF-NOTA-FAPI-04 PET/CT: a prospective cohort study.
    2026 · Eur J Nucl Med Mol Imaging · Prospective
  4. Head-to-Head comparison of [18F]AlF-NOTA-TATE and [68Ga]Ga-DOTA-TATE PET/CT in patients with neuroendocrine tumors: a prospective study.
    2026 · Eur J Nucl Med Mol Imaging · Prospective
  5. Imaging pancreatic cancer with [18F]F-AlF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT): distribution patterns and therapeutic implications.
    2025 · Clin Radiol · Prospective
  6. Evaluation of the safety, biodistribution, dosimetry of [18F]AlF-NOTA-LM3 and head-to-head comparison with [68Ga]Ga-DOTATATE in patients with well-differentiated neuroendocrine tumors: an interim analysis of a prospective trial.
    2024 · Eur J Nucl Med Mol Imaging · Prospective
  7. First experience of 18F-alfatide in lung cancer patients using a new lyophilized kit for rapid radiofluorination.
    2013 · J Nucl Med · Clinical study
  8. Case Report: FAPI PET/CT detected occult contralateral DCIS and supraclavicular metastasis, guiding neoadjuvant therapy in synchronous bilateral breast cancer.
    2026 · Front Oncol · Case report
  9. Incidental Uptake of 18 F-AlF-NOTA-pentixather PET/CT in Anaplastic Thyroid Carcinoma.
    2026 · Clin Nucl Med · Case report

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 22 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 23554506: 'NOTA-PRGD2'.
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