Tracers / [61Cu]CuCl2
[61Cu]CuCl2
Also written as [61Cu]CuCl2; [Cu-61]CuCl2; copper-61 chloride
- Radionuclide
- Cu-61 t½ 200 min
- Modality
- PET
- Production route
- Cyclotron solid target
- Stage
- Research
- Syntheses indexed
- 3
What it is
- Compound class
- Radiometal starting material
- Target / mechanism
- n/a
- Clinical application
- [61Cu]CuCl2 solution used to radiolabel 61Cu radiopharmaceuticals PMID 33151400 / DOI 10.1186/s41181-020-00108-7
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=copper+Cu+61+chloride
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | vendor cassette | SPE | 90.4 ± 3.2 yes | — | natNi Alfa Aesar | 33151400 2020 EJNMMI Radiopharm Chem transferred to an automated FASTlab chemistry module — an average radiochemical yield of 90.4 ± 3.2% (N = 5) |
| — | custom manifold | — | 84 ± 5% (AG1-x8) / 83 ± 7% (TK201) yes | over 99.6% | 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid (TETA) | 38180574 2024 EJNMMI Radiopharm Chem |
| — | — | SPE | 63.0 ± 15.0% | >95% | natural zinc | 33183218 2021 Curr Radiopharm using a commercially available Synthera ® Extension module (IBA, Louvain-la-Neuve, Belgium) — with an average yield of 63.0 ± 15.0%, in a maximum volume of 5 mL |
Precursor
- Common precursor
- Cyclotron irradiation of nickel solid targets followed by chemical separation PMID 33151400 / DOI 10.1186/s41181-020-00108-7
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Alfa Aesar
- Typical final purification
- Ion exchange
Need this precursor?We can point you to suppliers for [61Cu]CuCl2, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); STAGE 17.4: fixed a rule bug -- simple-salt check missed '[61Cu]CuCl2' because the isotope prefix broke the exact-name match used for GaCl3/CuCl2/ZrCl4; corrected to match the GaCl3 starting-material pattern (no HPLC UV, no chromatographic RCP test)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [61Cu]CuCl2.
Get in touchNotes
Not a tracer.