Tracer library / [11C]SSI-4
Structure of SSI-4 (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 118884425

[11C]SSI-4

Also written as [11C]SSI-4; [C-11]SSI-4
Radionuclide
C-11 t½ 20.36 min
Modality
PET
Production route
—
Stage
Preclinical
Syntheses indexed
1
Hepatobiliary and pancreatic cancerRenal cell carcinoma

What it is

Compound class
SCD1 inhibitor-based small molecule radiotracer (isonicotinamide carboxamide)
Target / mechanism
Stearoyl CoA desaturase 1 (SCD1) PMID 37409698
Clinical application
Hepatocellular carcinoma and renal cell carcinoma tumor xenograft models PMID 37409698
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Synthra MeIplus
Synthra
—HPLC+SPE4.14 ± 0.44%
not corrected
98.45 ± 1.43%—37409698
2023 Mol Pharm
direct [11C]CO2 fixation on the Synthra MeIplus module - afforded a 4.14 ± 0.44% (decay uncorrected, n = 10) radiochemical yield based on starting [11]CO2 radioactivity

Need this precursor?We can point you to suppliers for [11C]SSI-4, or handle the enquiry for you.

Get in touch

Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [11C]SSI-4.

Get in touch

Notes

Added from reverse module search (stage 6); 1 article(s) with C-11.
Ask a question