Tracers / [11C]SSI-4
[11C]SSI-4
Also written as [11C]SSI-4; [C-11]SSI-4
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- SCD1 inhibitor-based small molecule radiotracer (isonicotinamide carboxamide)
- Target / mechanism
- Stearoyl CoA desaturase 1 (SCD1) PMID 37409698
- Clinical application
- Hepatocellular carcinoma and renal cell carcinoma tumor xenograft models PMID 37409698
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC+SPE | 4.14 ± 0.44% no | 98.45 ± 1.43% | — | 37409698 2023 Mol Pharm direct [11C]CO2 fixation on the Synthra MeIplus module — afforded a 4.14 ± 0.44% (decay uncorrected, n = 10) radiochemical yield based on starting [11]CO2 radioactivity |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]SSI-4.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11.