Tracers / [11C]PBR28
[11C]PBR28
Also written as [11C]PBR28; [C-11]PBR28; C-11 PBR28; N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide; PBR28
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- TSPO radioligand (acetamide-based, N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide derivative)
- Target / mechanism
- Binds translocator protein (TSPO, 18 kDa), a marker of microglial activation PMID 26839827
- Clinical application
- —
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
- —
Clinical use
- Typical injected activity
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- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC+SPE | 45-55% yes | >99% | p-phenol precursor 6 (N-(2-Hydroxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide) | 26839827 2015 Sci Pharm we optimized the radiolabeling procedure of [11C]PBR28 in GE-FXC, GE-FXMeI/FXM, and TRASIS AIO modules at the Wake Forest PET Center for clinical trials — The radiochemical yield was ~45–55% and the specific activity ranged from 8000–9500 mCi/μmol (n=15, decay corrected to EOS). |
| In-house / custom built | custom manifold | HPLC | 70-80% yes | >99% | desmethyl-PBR28 (4a), N-(2-hydroxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide | 19716298 2009 Bioorg Med Chem Lett The radiosynthesis was performed in an in-house automated multi-purpose 11C-radiosynthesis module, allowing measurement of specific radioactivity during synthesis.19,20 — produce the corresponding pure radiolabeled compound [11C]4b in 70-80% radiochemical yield, decay corrected to end of bombardment (EOB), based on [11C]CO2 |
| — | — | HPLC+SPE | 3.6% | >99% | desmethyl-PBR28 | 22503515 2012 Appl Radiat Isot using a GE TRACERlab FX(C-Pro) — Typical radiochemical yield using the optimized method is 3.6% yield (EOS, n=3) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]PBR28.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with C-11.