Tracer library / [11C]L-deprenyl-D2

Structure of L-deprenyl (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 26757

[11C]L-deprenyl-D2

Also written as [11C]L-deprenyl-D2; [C-11]L-deprenyl-D2

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 4

Neuroinflammation

What it is

Compound class: MAO-B inhibitor (deuterated deprenyl analogue)
Target / mechanism: Monoamine oxidase-B (MAO-B) PMID 36557975
Clinical application: PET imaging of astrocytosis in neurodegenerative diseases PMID 29503851
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	—	HPLC+SPE	44 ± 13% decay-corrected	>99%	L-nordeprenyl-D2 free base	29503851 2017 EJNMMI Radiopharm Chem the commercial platform GE TRACERlab® FX C Pro - 44 ± 13% (n = 12) (end of synthesis, decay corrected) radiochemical yield from [11C]MeI after 35 min synthesis time
TRACERlab FX C Pro GE HealthCare	—	HPLC+SPE	24 ± 9% decay-corrected	—	L-nordeprenyl-D2 hydrochloride salt	29503851 2017 EJNMMI Radiopharm Chem the commercial platform GE TRACERlab® FX C Pro - Using the commercially available hydrochloride salt of L-nordeprenyl-D2, (Buccino et al. 2016), the overall radiochemical yield was 24 ± 9% (n = 10) (end of synthesis, decay corrected from [11C]MeI)
iMiDEV PMB-Alcen	custom manifold	HPLC+SPE	65-80% RCC	>97.7%	Desmethyl-L-deprenyl In-house / non-commercial (various)	36557975 2022 Molecules iMiDEV™ Automated Microfluidic Radiosynthesizer - The radiolabeling conversion was 65–80% with a microfluidic cassette.
TRACERlab FX C Pro GE HealthCare	—	—	37±15 decay-corrected	>99	—	26760951 2016 Appl Radiat Isot using the automated platform TRACERlab® FX-C Pro - (37±15)% (n=10) (end of synthesis, decay corrected from [(11)C]MeI) radiochemical yields

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: In-house / non-commercial (various)
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11.