Tracers / [11C]L-deprenyl-D2
[11C]L-deprenyl-D2
Also written as [11C]L-deprenyl-D2; [C-11]L-deprenyl-D2
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- MAO-B inhibitor (deuterated deprenyl analogue)
- Target / mechanism
- Monoamine oxidase-B (MAO-B) PMID 36557975
- Clinical application
- PET imaging of astrocytosis in neurodegenerative diseases PMID 29503851
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 44 ± 13% yes | over 99% | L-nordeprenyl-D2 free base | 29503851 2017 EJNMMI Radiopharm Chem the commercial platform GE TRACERlab® FX C Pro — 44 ± 13% (n = 12) (end of synthesis, decay corrected) radiochemical yield from [11C]MeI after 35 min synthesis time |
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 24 ± 9% yes | — | L-nordeprenyl-D2 hydrochloride salt | 29503851 2017 EJNMMI Radiopharm Chem the commercial platform GE TRACERlab® FX C Pro — Using the commercially available hydrochloride salt of L-nordeprenyl-D2, (Buccino et al. 2016), the overall radiochemical yield was 24 ± 9% (n = 10) (end of synthesis, decay corrected from [11C]MeI) |
| iMiDEV PMB-Alcen | custom manifold | HPLC+SPE | 65-80% (RCC) | >97.7% | Desmethyl-L-deprenyl In-house / non-commercial (various) | 36557975 2022 Molecules iMiDEV™ Automated Microfluidic Radiosynthesizer — The radiolabeling conversion was 65–80% with a microfluidic cassette. |
| — | — | — | 37±15 yes | >99 | — | 26760951 2016 Appl Radiat Isot using the automated platform TRACERlab® FX-C Pro — (37±15)% (n=10) (end of synthesis, decay corrected from [(11)C]MeI) radiochemical yields |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]L-deprenyl-D2.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11.