Tracers / [11C]ibrutinib
[11C]ibrutinib
Also written as [11C]Ibrutinib; [C-11]Ibrutinib
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- Bruton's tyrosine kinase (BTK) inhibitor (small molecule, ibrutinib analog)
- Target / mechanism
- Bruton's tyrosine kinase (BTK) PMID 27043721
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
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- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX (model not stated) GE HealthCare | — | HPLC | — | — | — | 37513867 2023 Pharmaceuticals (Basel) Recently, Scott, Shao, and co-workers developed an automated and good manufacturing practice (GMP)-compliant "in-loop" 11C-carbonylation procedure using a modified GE TracerLabTM synthesis platform — three clinically relevant BTK inhibitors, [11C]ibrutinib, [11C]tolebrutinib, and [11C]evobrutinib, were synthesized at good RCYs |
| TRACERlab FX C Pro GE HealthCare | custom manifold | HPLC+SPE | 5% no | >99% | precursor 11 Bristol-Myers Squibb | 27043721 2016 Bioconjug Chem the procedure was fully automated on a GE TRACERLab FXC-Pro synthesis module — gave 150 mCi of isolated and formulated product (5% non-decay corrected RCY based upon [11C]CO2; RCP >99%; specific activity = 55 mCi/μmol; pH = 6.0) |
| TracerMaker Scansys Laboratorieteknik | — | HPLC+SPE | 5.4 ± 2.5% no | >99% | 3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-amine Bristol Myer-Squibb Pharmaceuticals, Princeton, NJ, USA | 39355638 2021 Front Nucl Med The radiosynthesis of [11C]ibrutinib was fully automated using a commercial TracerMaker™ 11C synthesis platform. — [11C]Ibrutinib was synthesized in 5.4 ± 2.5% (n = 9) RCY (non-decay corrected) relative to [11C]CO2 |
| TracerMaker Scansys Laboratorieteknik | — | HPLC | 5 no | — | — | 39831838 2025 ChemistryOpen was delivered to a TracerMaker synthesis platform (Scansys Laboratorieteknik, Denmark) — The fully automated syntheses yielded [11C]Ibrutinib in RCY of 5 % |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11.