Tracers / [11C]GR103545
[11C]GR103545
Also written as [11C]GR103545; [C-11]GR103545
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 1
What it is
- Compound class
- kappa opioid receptor agonist PET radiotracer
- Target / mechanism
- kappa opioid receptor (KOR) PMID 31752279
- Clinical application
- Human brain imaging in cocaine-use disorder, major depressive disorder, and neuropsychiatric disease research PMID 24844744
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | ≥90% | desmethoxycarbonyl precursor | 21315277 2011 Nucl Med Biol The TRACERLab FXC automated synthesis module was used to carry out the two-step, one-pot procedure. |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]GR103545.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with C-11.