Tracer library / [11C]GR103545

Structure of GR103545 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 6603856

[11C]GR103545

Also written as [11C]GR103545; [C-11]GR103545

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 1

CNS receptor and transporter imaging

What it is

Compound class: kappa opioid receptor agonist PET radiotracer
Target / mechanism: kappa opioid receptor (KOR) PMID 31752279
Clinical application: Human brain imaging in cocaine-use disorder, major depressive disorder, and neuropsychiatric disease research PMID 24844744
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	—	—	—	≥90%	desmethoxycarbonyl precursor	21315277 2011 Nucl Med Biol The TRACERLab FXC automated synthesis module was used to carry out the two-step, one-pot procedure.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.