Tracer library / [11C]erlotinib

Structure of erlotinib (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 176870

[11C]erlotinib

Also written as [11C]erlotinib; [C-11]erlotinib

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Lung cancer

What it is

Compound class: erlotinib (EGFR tyrosine kinase inhibitor, small molecule)
Target / mechanism: Epidermal growth factor receptor (EGFR) PMID 29888317
Clinical application: Visualization of EGFR mutational status in cancer patients PMID 29888317
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	fixed tubing	HPLC+SPE	13.4 ± 6.2% decay-corrected	>99%	6-O-desmethyl-erlotinib (OSI-420) Syncom B.V.	29888317 2018 EJNMMI Radiopharm Chem were performed in two different TRACERlab™ FX C Pro synthesis modules (GE Healthcare, Uppsala, Sweden) - decay-corrected radiochemical yields of 13.4 ± 6.2% and 16.1 ± 4.9% starting from in-target produced [11C]CO2 and [11C]CH4, respectively
TRACERlab FX C Pro GE HealthCare	fixed tubing	HPLC+SPE	16.1 ± 4.9% decay-corrected	>98%	6-O-desmethyl-erlotinib (OSI-420) Syncom B.V.	29888317 2018 EJNMMI Radiopharm Chem were performed in two different TRACERlab™ FX C Pro synthesis modules (GE Healthcare, Uppsala, Sweden) - decay-corrected radiochemical yields of 13.4 ± 6.2% and 16.1 ± 4.9% starting from in-target produced [11C]CO2 and [11C]CH4, respectively

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Syncom B.V.
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 29888317: 'The precursor 6-O-desmethyl-elotinib (OSI-420; GMP grade) was purchased from Syncom B.V. (Groningen, Netherlands)'.