Tracer library / [11C]AMT
[11C]AMT
Also written as [11C]AMT; [C-11]AMT; AMT; C-11 AMT; C-11-AMT
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- alpha-[11C]methyl-L-tryptophan, a tryptophan-based amino acid PET radiotracer
- Target / mechanism
- Tryptophan hydroxylase (serotonin synthesis pathway) / tryptophan metabolism PMID 39179904
- Clinical application
- Healthy volunteers undergoing functional PET/fMRI imaging of reward processing and serotonin synthesis dynamics PMID 39179904
- Theranostic pair
- [211At]At-211-AMT
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 C GE HealthCare | — | — | 13 ± 7.5 % decay-corrected | >95 % | — | 40306184 2025 Nucl Med Biol adaptation of the GE TRACERlab FX2 C module for [11C]AMT production using both a half-manual approach and a semi-automated method incorporating a 16-way valve system - decay-corrected radiochemical yields of 13 ± 7.5 % (half-manual) |
| TRACERlab FX2 C GE HealthCare | — | — | 10.4 ± 4.1 % decay-corrected | >95 % | — | 40306184 2025 Nucl Med Biol adaptation of the GE TRACERlab FX2 C module for [11C]AMT production using both a half-manual approach and a semi-automated method incorporating a 16-way valve system - 10.4 ± 4.1 % (semi-automated) |
| Modular-Lab (model not stated) Eckert & Ziegler | — | HPLC | 5.3±1.2% not corrected | >99% | — | 27150033 2016 Nucl Med Biol based on an Eckert and Ziegler Modular-Lab system - 5.3±1.2% (n=6, non-decay-corrected) overall radiochemical yield |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]AMT.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with C-11.