Tracer library / [11C]acetoacetate
[11C]acetoacetate
Also written as [11C]Acetoacetate; [C-11]Acetoacetate
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- carboxylic acid (short-chain ketone body, acetoacetate)
- Target / mechanism
- —
- Clinical application
- Assessment of ketone body utilization / oxidative metabolism PMID 41452397
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 C GE HealthCare | custom manifold | HPLC | 4.67 ± 1.36% decay-corrected | 97.1 ± 1.3% | lithium enolate of acetone (from…lithium enolate of acetone (from isopropenyl acetate and MeLi) Sigma-Aldrich | 41452397 2025 EJNMMI Radiopharm Chem a GE TRACERlab FX2 C module - The decay-corrected RCY was 4.67 ± 1.36% after an average synthesis time of 15 min |
| — GE HealthCare | custom manifold | SPE | 16.1 ± 1.1% not corrected | 97 ± 2% | chloroacetone (17-Cl) | 37608567 2024 J Labelled Comp Radiopharm Following the standard automated [11C]carbonylation protocol, the loop mixture was quenched with 0.1M NaOH - corresponding to 16.1 ± 1.1% non-decay corrected RCY |
| AllinOne (AiO) Trasis | — | SPE | 35% decay-corrected | 95% | isopropenylacetate (IPA) Sigma-Aldrich | 28806598 2017 Appl Radiat Isot TRASIS AllInOne (AIO) is a commonly used radiochemistry module for clinical GMP-grade radiopharmaceutical production - 1-[11C]acetoacetate was synthesized with high radiochemical purity (95%) and specific activity (~ 66.6 GBq/µmol, n = 30) with 35% radiochemical yield, decay corrected to end of synthesis. |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Sigma-Aldrich
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [11C]acetoacetate, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]acetoacetate.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11.