Tracers / [11C]6-bromopurine
[11C]6-bromopurine
Also written as [11C]6-bromopurine; [C-11]6-bromopurine
- Radionuclide
- C-11 t½ 20.36 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical (non-clinical toxicity study and human dosimetry estimates, prepared to advance to clinical use)
- Syntheses indexed
- 2
What it is
- Compound class
- 6-bromo-7-methylpurine derivative (small-molecule purine analogue)
- Target / mechanism
- Measures multidrug resistance-associated protein 1 (MRP1) transport activity PMID 38683266
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX C Pro GE HealthCare | — | — | 16.8 ± 1.7 % yes | >98 % | 6-bromopurine | 27090254 2016 EJNMMI Res in a Tracerlab FX C Pro synthesis module with slight modifications compared to the literature — [11C]7m6BP was obtained in a radiochemical yield of 16.8 ± 1.7 % (n = 12) (based on [11C]methyl triflate, decay-corrected) |
| TRACERlab FX2 C GE HealthCare | fixed tubing | HPLC+SPE | 20.5 ± 5.2% yes | >99% | 6-bromo-7H-purine Mihulka, s.r.o., Opava-Jaktar, Czech Republic | 38683266 2024 EJNMMI Radiopharm Chem The automated radiosynthesis was performed in a TRACERlab™ FX2 C synthesis module (GE Healthcare, Uppsala, Sweden). — decay-corrected radiochemical yield of 20.5 ± 5.2%, based on starting [11C]methyl iodide |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]6-bromopurine.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 38683266: '6-Bromo-7H-purine was synthesised with a purity of 99.2% (HPLC) by Mihulka, s.r.o.'. Stage set/updated at stage 23 from PMID 38683266: 'Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates.'.