Tracer library / [11C]6-bromopurine

Structure of 6-bromopurine (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 5287830

[11C]6-bromopurine

Also written as [11C]6-bromopurine; [C-11]6-bromopurine

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

What it is

Compound class: 6-bromo-7-methylpurine derivative (small-molecule purine analogue)
Target / mechanism: Measures multidrug resistance-associated protein 1 (MRP1) transport activity PMID 38683266
Clinical application: Measurement of MRP1 transport activity in tissues, developed toward clinical use in humans PMID 38683266
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX2 C GE HealthCare	fixed tubing	HPLC+SPE	20.5 ± 5.2% decay-corrected	>99%	6-bromo-7H-purine Mihulka, s.r.o., Opava-Jaktar, Czech Republic	38683266 2024 EJNMMI Radiopharm Chem The automated radiosynthesis was performed in a TRACERlab™ FX2 C synthesis module (GE Healthcare, Uppsala, Sweden). - decay-corrected radiochemical yield of 20.5 ± 5.2%, based on starting [11C]methyl iodide

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Mihulka, s.r.o.
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with C-11. Compound class inferred from precursor name (not stated outright) -- PMID 38683266: '6-Bromo-7H-purine was synthesised with a purity of 99.2% (HPLC) by Mihulka, s.r.o.'. Stage set/updated at stage 23 from PMID 38683266: 'Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates.'. | Stage 30 (2026-09-18): Stage was 'preclinical (non-clinical toxicity study and human dosimetry estimates, prepared to advance to clinical use)'; normalised to 'Preclinical', original wording kept here.