Tracer library / [211At]At-211-MX35

[211At]At-211-MX35

Also written as At-211-MX35

Radionuclide: At-211 t½ 431 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 2

Gynaecological cancer

What it is

Compound class: Monoclonal antibody (murine MX35, anti-NaPi2b) radiolabeled with astatine-211
Target / mechanism: Targets NaPi2b cell surface glycoprotein on ovarian cancer cells PMID 32987283
Clinical application: Alpha-radioimmunotherapy of minimal residual ovarian cancer PMID 25970341
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	63 (±7) %	96 (±3) %	MX35 Ludwig Institute for Cancer Research, Zürich, Switzerland	32987283 2021 Transl Oncol The antibodies were conjugated with N-succinimidyl 3-(trimethylstannyl)benzoate (m-MeATE) and radiolabeled as previously described - The overall radiochemical yield was 63 (±7) %.
Manual synthesis	—	SPE	74% 77%	>95%	N-succinimidyl 3-(trimethylstannyl)benzoate…N-succinimidyl 3-(trimethylstannyl)benzoate (m-MeATE) Toronto Research Chemicals	25970341 2015 PLoS One Astatination was performed as previously described [18]. Briefly; a 50–100 MBq dry astatine residue was activated by adding N-iodosuccinimide in methanol containing 1% acetic acid. - Radiochemical yields were 42% and 46% for iodination and 74% and 77% for astatination of murine MX35 and Rebmab200, respectively.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Ludwig Institute for Cancer Research, Toronto Research Chemicals
Typical final purification: —

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 32987283: 'The murine IgG mAb MX35, directed against the NaPi2b cell surface glycoprotein, was developed at the Memorial Sloan-Kettering Cancer Center'.