Tracers / [18F]FTYR

[18F]FTYR

Also written as 2-[18F]fluoro-L-tyrosine; [18F]F-Tyr; [18F]FTYR; [18F]L-Tyrosine; [F-18]F-Tyr; [F-18]FTYR; [F-18]L-Tyrosine

Radionuclide: F-18 t½ 109.7 min
Modality: PET
Production route: Cyclotron liquid target
Stage: Research
Syntheses indexed: 3

Amino acid transport and protein synthesis Pan-cancer / multiple tumour types

What it is

Compound class: Amino acid
Target / mechanism: Amino-acid (system L) transport; incorporation into protein synthesis PMID 12831987 / DOI 10.1016/s0969-8051(03)00023-4; PMID 12150277 / DOI 10.1016/s0969-8043(02)00091-x
Clinical application: PET imaging of amino-acid transport / protein synthesis; tumour imaging and whole-body tumour staging PMID 12150277 / DOI 10.1016/s0969-8043(02)00091-x; PMID 17475959 / DOI 10.2967/jnumed.106.038216
Theranostic pair: —

Regulatory status

FDA: No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluoro-L-tyrosine
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: 300 MBq PMID 17475959 / DOI 10.2967/jnumed.106.038216
Uptake time: ~30 min after injection PMID 17475959 / DOI 10.2967/jnumed.106.038216

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built	custom manifold	HPLC+SPE	— yes	—	Boc2-2-(SnMe3)Tyr(Boc)-OEt ABX	29244780 2017 Molecules All automated radiosyntheses were carried out in a home-made synthesis module.
—	—	HPLC	50.5 ± 2.7% yes	—	—	26011311 2015 J Labelled Comp Radiopharm on a GE FASTlab synthesizer — [(18)F]FDOPA and [(18)F]FTYR were produced in 36.3 ± 3.0% (n = 8) and 50.5 ± 2.7% (n = 10) FASTlab radiochemical yield (decay corrected)
—	—	HPLC	—	—	O,N-di-Boc-2-triethylstannyl-L-tyrosine ethylester	12150277 2002 Appl Radiat Isot

Precursor

Common precursor: Electrophilic route: O,N-di-Boc-2-triethylstannyl-L-tyrosine ethyl ester (2-trialkylstannyl tyrosine); nucleophilic route: Ni-(S)-BPB-(S)-Tyr(CH2CH2OTs) complex PMID 12150277 / DOI 10.1016/s0969-8043(02)00091-x; PMID 19621048 / DOI 10.1134/s1068162009030042
Suppliers seen in the literature: ABX GmbH (Radeberg, Germany) (Boc-2-(SnMe3)Tyr(Boc)-OEt)
Cited suppliers in indexed syntheses: ABX
Typical final purification: HPLC

Need this precursor?We can point you to suppliers for [18F]FTYR, or handle the enquiry for you.

Get in touch

Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]FTYR.

Get in touch