Tracer library / [125I]I-Ex-D3
[125I]I-Ex-D3
- Radionuclide
- I-125 t½ 85666 min
- Modality
- Therapy
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- Exendin-4 derived peptide (Ex-D3, Glu3Asp substitution with C-terminal Cys, Ex-D3-C40) for site-specific 125I labeling
- Target / mechanism
- GLP-1 receptor (GLP-1R) agonist binding to pancreatic beta cells PMID 40076236
- Clinical application
- GLP-1R imaging of pancreatic beta-cells, e.g. for insulinoma-related applications PMID 40076236
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC | 43% | >99% | Ex-D3-C40 | 40076236 2025 Molecules For radiolabeling peptides, [125I]IPM in acetonitrile was reacted with Ex-D3-C40, Ex-4-C40, or Ex-F1-C40 (100 μg dissolved in PBS) for 30 min at room temperature. - The radiochemical yields for [125I]I-Ex-D3, [125I]I-Ex-4, and [125I]I-Ex-F1 were 43%, 54%, and 59%, respectively |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40076236. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40076236: 'Ex-D3-C40, Ex-4-C40, or Ex-F1-C40 were dissolved in PBS (pH 7.4) and added with IPM (1 eq.) to acetonitrile.'.