Tracers / [18F]SFB
[18F]SFB
Also written as 4-[18F]fluorobenzoic acid; [18F]SFB; [F-18]SFB; GE-274; N-succinimidyl 4-[18F]fluorobenzoate; N-succinimidyl-4-[18F]fluorobenzoate
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- n/a
- Production route
- Cyclotron liquid target
- Stage
- n/a
- Syntheses indexed
- 7
What it is
- Compound class
- Prosthetic group / synthon
- Target / mechanism
- n/a
- Clinical application
- n/a
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=succinimidyl+fluorobenzoate
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN GE HealthCare | custom manifold | SPE | 38% no | >95% | 4-(ethoxycarbonyl)-N,N,N-trimethylbenzenaminium triflate | 21769163 2011 J Labelled Comp Radiopharm the Tracerlab was configured as shown in Figure 12 — Typical yields of [18F]SFB using this method were 38% (non-decay corrected, n = 20) and radiochemical purity is always >95%. |
| Neptis (model not stated) ORA | custom manifold | HPLC | 42 + 4% yes | >99% | N-succinimidyl 4-(tri-n-butylstannyl)-benzoate abcr GmbH | 36333403 2022 Sci Rep Production and use of [18F]SFB were implemented on a radiosynthesis unit (Neptis®). — [18F]SFB was obtained after HPLC purification in a yield of 42 + 4% and a radiochemical purity (RCP) > 99% (n = 6). |
| AllinOne (AiO) Trasis | vendor cassette | SPE | 44 ± 4% yes | >90% | ethyl-4-(trimethylammonium)benzoate ABX | 39048805 2024 EJNMMI Radiopharm Chem the AllInOne (AiO) module (Trasis) — a RCY d.c. of 44 ± 4% (n = 13) |
| — | — | HPLC | — | — | — | 30710291 2019 Methods Mol Biol |
| — | — | none | 42% yes | — | — | 21267662 2011 Mol Imaging Biol GE FASTlab™ synthesizer — 42% decay-corrected yield in 57 min (n = 24) |
| — | — | — | 32% yes | — | — | 21267662 2011 Mol Imaging Biol GE FASTlab™ synthesizer — The lower d.c. yield obtained (32% (n = 15)) |
| — | — | — | 46±5% yes | >99% | — | 16935516 2007 Appl Radiat Isot a modified Siemens/CTI chemistry process control unit (CPCU) double vessel [18F]FDG module — decay corrected yields of ... 46+/-5% (n=4) for [18F]SFB |
Precursor
- Common precursor
- Spirocyclic iodonium ylide precursor (one-step route); classical routes use a 4-(trimethylammonium or nitro or boronate)-benzoate ester precursor PMID 31546683 / DOI 10.3390/molecules24193436
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX, abcr GmbH
- Typical final purification
- HPLC
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic solvent confirmed in synthesis data (PMID 21769163) -> GC residual solvents; conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]SFB.
Get in touchNotes
Synthon, not a tracer. Keep out of the main tracer list on the site.