Tracers / [18F]MK-6240
[18F]MK-6240
Also written as [18F]MK-6240; [18F]MK6240; [F-18]MK-6240; [F-18]MK6240; F-18 MK-6240; F-18 MK6240; F-18-MK6240
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Approved
- Syntheses indexed
- 2
What it is
- Compound class
- Small molecule
- Target / mechanism
- Aggregated tau (neurofibrillary tangles) PMID 28185305 / DOI 10.1002/jlcr.3496
- Clinical application
- Detection of tau (neurofibrillary-tangle) pathology in Alzheimer's disease PMID 28185305 / DOI 10.1002/jlcr.3496
- Theranostic pair
- —
Regulatory status
- FDA
- Yes — 2026; TAUKLARIFY (florquinitau F 18); Cerveau Technologies / Lantheus; NDA 220496 Drugs@FDA, NDA 220496, approved 2026-08-13 — https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=florquinitau
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- Tauklarify (US, FDA)
Clinical use
- Typical injected activity
- —
- Uptake time
- Brain PET acquired ~90-110 min after injection (dynamic and dual-time-window protocols also used) PMID 41591778 / DOI 10.1001/jamanetworkopen.2025.54524
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC | 9.8% ± 1.8% yes | — | N-[(tert-butoxy)carbonyl]-N-(6-nitro-3-[1H-pyrrolo[2,3-c]pyridin-1-yl]isoquinolin-5-yl) carbamate | 30426529 2019 J Labelled Comp Radiopharm The synthesis was performed automatically with a single-use cassette on an IBA Synthera+ synthesis module. — resulting in an isolated radiochemical yield of 9.8% ± 1.8% (n = 3) calculated from the end of bombardment (5.2% ± 1.0% calculated from the end of synthesis). |
| — | — | HPLC | 7.5% ± 1.9% no | — | 5-diBoc-6-nitro precursor | 28185305 2017 J Labelled Comp Radiopharm a commercially available radiosynthesis module, GE Healthcare TRACERlab FXFN — in an uncorrected radiochemical yield of 7.5% ± 1.9% (relative to starting [18 F]fluoride) |
Precursor
- Common precursor
- Bis-Boc-protected 6-nitro precursor; nucleophilic [18F]fluorination (SNAr displacing the nitro group) then acid deprotection and HPLC PMID 28185305
- Suppliers seen in the literature
- —
- Typical final purification
- —
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added at user request.