Tracer library / [18F]FES
[18F]FES
Also written as [18F]FES; [18F]Fluoroestradiol; [F-18]FES; [F-18]Fluoroestradiol; F-18 FES; F-18 Fluoroestradiol; FES
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 5
What it is
- Compound class
- Radiolabelled estradiol analogue (16α-[18F]fluoro-17β-estradiol)
- Target / mechanism
- Estrogen receptor (ER) — binding affinity comparable to endogenous estradiol PMID 17920354
- Clinical application
- PET imaging adjunct for detecting ER-positive lesions in patients with recurrent or metastatic breast cancer FDA label NDA212155
- Theranostic pair
- —
Regulatory status
- FDA
- 2020, Cerianna, GE Healthcare FDA (Drugs@FDA/openFDA): NDA212155, approved 2020-05-20
- EMA (centralised)
- No EMA medicines register export (2026-09-09): no 'fluoroestradiol' entry
- Other approvals
- —
- Brand names
- Cerianna
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab (model not stated) Eckert & Ziegler | custom manifold | HPLC | 40.0 ± 5.0% decay-corrected | >97% | MMSE (3-methoxymethyl-16β,…MMSE (3-methoxymethyl-16β, 17β-epiestriol-O-cyclic sulfone) ABX | 23762549 2013 Int J Mol Imaging the E & Z Modular Lab synthesizer - The decay-corrected radiochemical yield for the qualification runs was 40.0 ± 5.0% (N = 12). |
| — | — | HPLC | — | >99% | — | 17718929 2007 J Pharm Pharm Sci |
| Synthra RNplus Synthra | — | SPE | 40%-45% not corrected | — | — | 35996821 2022 J Labelled Comp Radiopharm the Synthra RNplus research automated platform - the yield was considerably improved (40%-45% ndc) |
| In-house / custom built Laboratory | — | HPLC+SPE | 30-35% decay-corrected | >99% | cyclic sulfate precursor | 32174461 2020 Appl Radiat Isot our home-built automated multi-purpose 18F-radiosynthesis module - the radiochemical yield was 30-35% decay corrected to end of bombardment (EOB), based on H[18F]F |
| TRACERlab FX FN GE HealthCare | — | HPLC | 50 ± 2.35% decay-corrected | 96.1 ± 0.3% | — | 22044863 2012 Nucl Med Commun using a TRACERlab FXFN module - the decay-corrected radiochemical yield of [¹⁸F]FES was 50 ± 2.35% (n=4) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [18F]FES, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FES.
Get in touchNotes
Added from reverse module search (stage 6); 9 article(s) with F-18.