Tracers / [18F]fluoroazomycin-2'-deoxyribofuranoside

[18F]fluoroazomycin-2'-deoxyribofuranoside

Also written as [18F]fluoroazomycin-2'-deoxyribofuranoside

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: preclinical
Syntheses indexed: 1

Tumour hypoxia

What it is

Compound class: 2-nitroimidazole (azomycin) nucleoside derivative
Target / mechanism: Reductive trapping in hypoxic cells (2-nitroimidazole hypoxia marker, mimicking nucleoside transport) PMID 27693670
Clinical application: Tumor hypoxia imaging in colon carcinoma xenograft model PMID 27693670
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	10.9±2.4% no	>98%	β-5	27693670 2016 Nucl Med Biol β-5 was radiolabeled in a GE TRACERlab FXF-N synthesizer in DMSO and deprotected with NH4OH to give [18F]FAZDR ([18F]-β-8). — [18F]FAZDR was obtained in non-corrected yields of 10.9±2.4% (9.1±2.2GBq, n=4) 60min EOB

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18.