Tracer library / [18F]AV-45
[18F]AV-45
Also written as [18F]AV-45; [18F]florbetapir; [F-18]AV-45; [F-18]florbetapir; AV-45; F-18 AV-45; F-18 Florbetapir
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 6
What it is
- Compound class
- Radiolabelled stilbene derivative (amyloid-binding small molecule)
- Target / mechanism
- β-amyloid neuritic plaques (Kd approx. 3.7 nM in postmortem brain homogenates) PMID 23527322
- Clinical application
- PET imaging of the brain to estimate β-amyloid neuritic plaque density in adults with cognitive impairment, for evaluation of Alzheimer's disease and other causes of cognitive decline FDA label NDA202008
- Theranostic pair
- —
Regulatory status
- FDA
- 2012, Amyvid, Avid Radiopharmaceuticals (Eli Lilly) FDA (Drugs@FDA/openFDA): NDA202008, approved 2012-04-06
- EMA (centralised)
- 2013, Amyvid, Eli Lilly EMA medicines register export (2026-09-09): EMEA/H/C/002422, 'Authorised', authorised 14 Jan 2013
- Other approvals
- —
- Brand names
- Amyvid
Clinical use
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN GE HealthCare | fixed tubing | HPLC | 14.8 ± 2.1% not corrected | >95% | AV-45 precursor (O-tosylated precursor) Wuxi Jiangyuan Industrial Technology and Trade Corporation | 35494660 2022 Front Chem Radiochemical synthesis and purification of [18F] AV-45 was carried out using a Tracerlab FXF-N Synthesizer - the average non-decay corrected radiochemical yield of [18F]AV-45 was 14.8 ± 2.1% (n = 4) |
| BNU F-A2 | custom manifold | SPE | 33.6 ± 5.2% (no decay corrected); 50.1 ± 7.9% (decay corrected) decay-corrected | > 95% | 1 (-OTs derivative) | 21055622 2010 Nucl Med Biol a radiosynthesis module (BNU F-A2) - the automated synthesis yield was 33.6 ± 5.2% (no decay corrected, n = 4), 50.1 ± 7.9% (decay corrected) in 50 min at a quantity level of 10~100 mCi (370~3700 MBq) |
| — | — | SPE | 42.7 ± 5.9% decay-corrected | >95% | O-tosylated precursor | 31697847 2020 J Labelled Comp Radiopharm |
| TRACERlab FX FN GE HealthCare | — | SPE | 14.2% | >95% | — | 37526186 2024 Curr Med Chem produced in a simple, stable, and repeatable manner on the Tracerlab FXF-N platform - the radiochemical yield was 14.2 % ± 2.7% (n = 6) |
| AllinOne (AiO) Trasis | — | — | 31.0%±2.8% not corrected | >98 | AV-105 | 38149774 2023 Hell J Nucl Med can be easily and quickly prepared by the All in One radiochemical synthesis module - the uncorrected synthesis efficiency was about 31.0%±2.8% |
| Sumitomo synthesizer Sumitomo | — | — | 25.4±7.7% | 95.3±2.2% | tosylate precursor | 20638295 2010 Appl Radiat Isot using a tosylate precursor with Sumitomo modules for radiosynthesis under GMP-compliant conditions - The overall yield was 25.4+/-7.7% |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- [Safety and Effectiveness of NEPTIS Plug-01 and Florbetapir (18F) in Daily Clinical Setting: Based on the Post-Marketing Surveillance Study].2019 · Kaku Igaku · Clinical study
- CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts.2018 · Alzheimers Dement · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Wuxi Jiangyuan Industrial Technology and Trade Corporation
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [18F]AV-45, or handle the enquiry for you.
Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AV-45.
Get in touchNotes
Added from reverse module search (stage 6); 9 article(s) with F-18.