Tracer library / [18F]PM-PBB3

[18F]PM-PBB3

Also written as [18F]APN-1607; [18F]PM-PBB3; [F-18]APN-1607; [F-18]PM-PBB3; APN-1607; PM-PBB3

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Tau pathology

What it is

Compound class: Benzothiazole derivative (PBB3 analogue) tau PET tracer
Target / mechanism: Tau pathology PMID 34245396
Clinical application: Clinically used radiotracer for imaging tau pathology PMID 34245396
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built in-house	custom manifold	HPLC	16 ± 3.2 decay-corrected	99 ± 0.50	PBB3 (7) Shanghai ChemPartner, Shanghai, China	34245396 2021 EJNMMI Radiopharm Chem An automated multi-purpose synthesizer developed in-house was used for all the radiosynthetic runs in this study (Supplemental information: Fig. S1, Fukumura et al. 2007). - the radiochemical yield of [18F]PM-PBB3 based on the cyclotron-produced [18F]F− at EOS was 16 ± 3.2 % (n = 11)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Shanghai ChemPartner
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 4 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 34245396: '2-((1E,3E)-4-(6-(methylamino)pyridin-3-yl)buta-1,3-dienyl)benzo[d]thiazol-6-ol (PBB3; 7, Fig. 3)'.