Tracers / [18F]PM-PBB3
[18F]PM-PBB3
Also written as [18F]APN-1607; [18F]PM-PBB3; [F-18]APN-1607; [F-18]PM-PBB3; APN-1607; PM-PBB3
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- Benzothiazole derivative (PBB3 analogue) tau PET tracer
- Target / mechanism
- Tau pathology PMID 34245396
- Clinical application
- Clinically used radiotracer for imaging tau pathology PMID 34245396
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| In-house / custom built in-house | custom manifold | HPLC | 16 ± 3.2 yes | 99 ± 0.50 | PBB3 (7) Shanghai ChemPartner, Shanghai, China | 34245396 2021 EJNMMI Radiopharm Chem An automated multi-purpose synthesizer developed in-house was used for all the radiosynthetic runs in this study (Supplemental information: Fig. S1, Fukumura et al. 2007). — the radiochemical yield of [18F]PM-PBB3 based on the cyclotron-produced [18F]F− at EOS was 16 ± 3.2 % (n = 11) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 34245396: '2-((1E,3E)-4-(6-(methylamino)pyridin-3-yl)buta-1,3-dienyl)benzo[d]thiazol-6-ol (PBB3; 7, Fig. 3)'.