Tracer library / [18F]PARPi
Structure of PARPi (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 130443213

[18F]PARPi

Also written as [18F]PARPi; [F-18]PARPi
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
Clinical research
Syntheses indexed
2

What it is

Compound class
PARP inhibitor-based small molecule (phthalazinone/niraparib-type PARP1 inhibitor)
Target / mechanism
—
Clinical application
—
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
vendor cassetteHPLC+SPE20.5 ± 3.4%
not corrected
≥97%PARPi precursor
Theragnostics Ltd.
35890164
2022 Pharmaceuticals (Basel)
the synthesis was automated on a Trasis AllinOne platform equipped with a Knauer pump - obtaining an RCY of 20.5 ± 3.4% n.d.c. (calculated on the final, reformulated product)
Manual synthesis—HPLC9.6%
not corrected
—tert-butyl…tert-butyl 4-(4-fluoro-3-(4-(4-nitrobenzoyl)piperazine-1-carbonyl)benzyl)-1-oxophthala-zine-2(1H)-carboxylate32391930
2020 J Labelled Comp Radiopharm
the yield of the manual synthesis, in our hands, has shown to be highly sensitive to precursor purity - yielding [18F]PARPi in 9.6% (non-decay corrected)

Precursor

Common precursor
—
Suppliers seen in the literature
—
Cited suppliers in indexed syntheses
Theragnostics Ltd.
Typical final purification
—

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 7 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 32391930: 'tert-butyl 4-(4-fluoro-3-(4-(4-nitrobenzoyl) piperazine-1-carbonyl) benzyl)-1-oxophthala-zine-2(1H)-carboxylate in 300 μL of dry DMSO was added'. Stage set/updated at stage 23 from PMID 35890164: '[18F]PARPi is currently undergoing clinical trials as a PET tracer for many applications.'. | Stage 30 (2026-09-18): Stage was 'clinical trials'; normalised to 'Clinical research', original wording kept here.
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