Tracers / [18F]P10A-1910
[18F]P10A-1910
Also written as [18F]P10A-1910; [F-18]P10A-1910
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- first-in-human
- Syntheses indexed
- 2
What it is
- Compound class
- quinazolinone-based PDE10A radioligand (isoindoline-dione/quinazolinone small molecule)
- Target / mechanism
- Phosphodiesterase 10A (PDE10A) PMID 36147528
- Clinical application
- PET/MRI quantification of PDE10A in human brain PMID 36147528
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 N GE HealthCare | custom manifold | HPLC+SPE | 12.4 ± 1.3% no | >95% | SCIDY 5 | 36147528 2022 Front Bioeng Biotechnol GE TRACERlab FX2N synthesis module — it was obtained in non-decay corrected radiochemical yields (n.d.c. RCYs) of 12.4 ± 1.3% |
| TRACERlab FX2 N GE HealthCare | custom manifold | HPLC+SPE | 16.8 ± 1.0% no | >95% | BPE 6 | 36147528 2022 Front Bioeng Biotechnol GE TRACERlab FX2N synthesis module — The boronic pinacol ester combined with copper and oxygen also delivered the radioligand with 16.8 ± 1.0% n. d.c. RCYs |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]P10A-1910.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 36147528: 'spirocyclic iodonium ylide (SCIDY) 2-(2-(3-(4-(((1R,5S)-4′,6′-dioxospiro [adamantane-2,2′- (Charbonneau et al., 1990; Francis et al., 2011)dioxan]-5′-ylidene)-λ3-iodaneyl)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione (5)'. Stage set/updated at stage 23 from PMID 36147528: 'we present the first automatic cGMP-level production of [18F]P10A-1910 and translational PET/MRI study in living human brains'.