Tracer library / [18F]P10A-1910
[18F]P10A-1910
Also written as [18F]P10A-1910; [F-18]P10A-1910
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 2
What it is
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 N GE HealthCare | custom manifold | HPLC+SPE | 12.4 ± 1.3% not corrected | >95% | SCIDY 5 | 36147528 2022 Front Bioeng Biotechnol GE TRACERlab FX2N synthesis module - it was obtained in non-decay corrected radiochemical yields (n.d.c. RCYs) of 12.4 ± 1.3% |
| TRACERlab FX2 N GE HealthCare | custom manifold | HPLC+SPE | 16.8 ± 1.0% not corrected | >95% | BPE 6 | 36147528 2022 Front Bioeng Biotechnol GE TRACERlab FX2N synthesis module - The boronic pinacol ester combined with copper and oxygen also delivered the radioligand with 16.8 ± 1.0% n. d.c. RCYs |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 36147528: 'spirocyclic iodonium ylide (SCIDY) 2-(2-(3-(4-(((1R,5S)-4′,6′-dioxospiro [adamantane-2,2′- (Charbonneau et al., 1990; Francis et al., 2011)dioxan]-5′-ylidene)-λ3-iodaneyl)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione (5)'. Stage set/updated at stage 23 from PMID 36147528: 'we present the first automatic cGMP-level production of [18F]P10A-1910 and translational PET/MRI study in living human brains'. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.