Tracer library / [18F]NAV4694
Structure of AZD4694 (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 24896605

[18F]NAV4694

Also written as [18F]AZD4694; [18F]NAV4694; [F-18]AZD4694; [F-18]NAV4694; AZD4694; F-18 AZD4694; F-18 NAV-4694
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Amyloid pathology

What it is

Compound class
Amyloid-binding PET radiotracer
Target / mechanism
Amyloid-beta (Aβ) PET tracer PMID 39437657
Clinical application
Alzheimer's disease amyloid PET imaging PMID 41038002
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
TRACERlab FX2 N
GE HealthCare
—SPE13 ± 3 %
decay-corrected
99 ± 0.5 %—41038002
2025 Appl Radiat Isot
The radiosynthesis was standardised in the FX2N synthesis module - providing the highest radiochemical yield of 13 ± 3 % (decay corrected)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Detection and staging of Alzheimer's disease by plasma pTau217 on a high throughput immunoassay platform.
    2024 · EBioMedicine · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 4 article(s) with F-18.
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