Tracers / [18F]NAV4694

[18F]NAV4694

Also written as [18F]AZD4694; [18F]NAV4694; [F-18]AZD4694; [F-18]NAV4694; AZD4694; F-18 AZD4694; F-18 NAV-4694

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Amyloid pathology

What it is

Compound class: —
Target / mechanism: Amyloid-beta (Aβ) PET tracer PMID 39437657
Clinical application: —
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	—	—	—	39437657 2024 EBioMedicine
—	—	SPE	13 ± 3 % yes	99 ± 0.5 %	—	41038002 2025 Appl Radiat Isot The radiosynthesis was standardised in the FX2N synthesis module — providing the highest radiochemical yield of 13 ± 3 % (decay corrected)

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 4 article(s) with F-18.