Tracer library / [18F]JNJ64413739

Structure of JNJ64413739 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 135390925

[18F]JNJ64413739

Also written as F-18 JNJ64413739; F-18-JNJ64413739; JNJ64413739

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Neuroinflammation

What it is

Compound class: P2X7 receptor imaging agent (nitropyridine-based small molecule)
Target / mechanism: Purinergic ion channel receptor 7 (P2X7R) PMID 39726781
Clinical application: Brain imaging in osteoporotic model rats; potential diagnosis of osteoporosis PMID 39726781
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
AllinOne (AiO) Trasis	custom manifold	HPLC+SPE	6.7% ± 3.8% not corrected	>97%	(S)-(6-methyl-1-(pyrimidin-2-yl)-1,4,6,7-tet…(S)-(6-methyl-1-(pyrimidin-2-yl)-1,4,6,7-tetrahydro-5H-[1,2,3] triazolo [4,5-c] pyridin-5-yl) (3-nitro-2-(trifluoromethyl)pyridin-4-yl) methanone In-house / non-commercial (various)	39726781 2024 Front Pharmacol The radiosynthesis was conducted on an AllinOne synthesis module - non-decay-corrected radiochemical yield of 6.7% ± 3.8% (n = 3)

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: In-house / non-commercial (various)
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 39726781: '(S)-(6-methyl-1-(pyrimidin-2-yl)-1,4,6,7-tetrahydro-5H-[1,2,3] triazolo [4,5-c] pyridin-5-yl) (3-nitro-2-(trifluoromethyl)pyridin-4-yl) methanone'. Stage set/updated at stage 39 from PMID 39726781: 'Small-animal PET/CT imaging studies were performed in sham and osteoporotic model rats.'.