Tracers / [18F]ICMT-11
[18F]ICMT-11
Also written as [18F]ICMT-11; [F-18]ICMT-11; F-18 ICMT-11; F-18 ICMT11; ICMT-11; ICMT11; isatin-5-sulfonamide
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Clinical research
- Syntheses indexed
- 3
What it is
- Compound class
- Isatin sulfonamide
- Target / mechanism
- Activated caspase-3 (apoptosis); isatin-5-sulfonamide caspase-3 inhibitor PMID 22575271 / DOI 10.1016/j.nucmedbio.2012.03.004; PMID 19805307 / DOI 10.1073/pnas.0901310106
- Clinical application
- Imaging of tumour apoptosis / early treatment response PMID 19805307 / DOI 10.1073/pnas.0901310106; PMID 30259091 / DOI 10.1007/s00259-018-4098-9
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=ICMT-11
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- ~150-160 MBq in healthy volunteers (159 +/- 3 MBq); ~330 MBq in patient studies PMID 23949910 / DOI 10.2967/jnumed.112.118760; PMID 30259091 / DOI 10.1007/s00259-018-4098-9
- Uptake time
- Dynamic PET ~60-65 min from injection; whole-body scans acquired up to 4 h post-injection PMID 23949910 / DOI 10.2967/jnumed.112.118760; PMID 30259091 / DOI 10.1007/s00259-018-4098-9
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC | 15.4 ± 0.1% no | 97.5 ± 0.1% | acetal protected tosylate precursor | 40148277 2025 Nat Commun |
| — | — | — | — | — | — | 22030029 2011 Bioorg Med Chem Lett |
| — | — | — | — | >98% | — | 22575271 2012 Nucl Med Biol the process was transferred onto a fully automated GE FASTlab synthesis platform for further development and optimisation |
Precursor
- Common precursor
- Acetal-protected tosylate precursor (SN2 [18F]fluorination, then acid-mediated deprotection and HPLC) PMID 32232626 / DOI 10.1007/s11307-020-01494-9
- Suppliers seen in the literature
- —
- Typical final purification
- HPLC
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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