Tracer library / [18F]FTHA

Structure of FTHA (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 132136

[18F]FTHA

Also written as [18F]fluoro-6-thia-heptadecanoic; [18F]FTHA; [F-18]fluoro-6-thia-heptadecanoic; [F-18]FTHA

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 4

Radiochemistry methodology

What it is

Compound class: fluorinated thia fatty acid analog (radiolabeled fatty acid, tosylate-derived thia-heptadecanoate precursor)
Target / mechanism: —
Clinical application: Imaging of fatty acid circulation/lipid metabolism by PET PMID 38543104
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX N Pro	—	HPLC+SPE	10.9±2.2 % not corrected	<93.5 %	benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoat…benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate ABX	31759313 2020 Nucl Med Biol All the syntheses were optimized in an automated TRACERlab FX-N Pro synthesizer. - for [18F]FTHA the uncorrected yield was 10.9±2.2 %
—	fixed tubing	HPLC+SPE	5.52 ± 2.38%	>95%	Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoat…Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate	38543104 2024 Pharmaceuticals (Basel) a former 11C-methylation vessel-based PET synthesizer (formerly Nuclear Interface, now General Electric Medical Systems, Uppsala, Sweden) was used. - a radiochemical yield (RCY) of 5.52 ± 2.38% (0.23–4.56 GBq) at the end of the synthesis (EOS)
ELIXYS FLEX/CHEM Sofie	vendor cassette	HPLC+SPE	13.01 ± 5.63%	>95%	Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoat…Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate	38543104 2024 Pharmaceuticals (Basel) Radiochemical production was performed on the Elixys Flex/Chem (Sofie Biosciences, Dulles, VA, USA), a commercially available automated disposable cassette-based radiosynthesizer. Purification and formulation were performed on the commercially available automated unit, Pure/Form (Sofie Biosciences). - a significantly increased RCY of 13.01 ± 5.63% (1.60–6.27 GBq) at the EOS starting from 19–26 GBq (Table 1)
In-house / custom built Laboratory	—	HPLC+SPE	13% ± 6.3% decay-corrected	—	—	29205456 2018 J Labelled Comp Radiopharm An automated synthesis device was constructed in-house for multistep nucleophilic 18 F-fluorination and a control system was developed. - The radiochemical yield of 14-(R,S)-[18 F]fluoro-6-thia-heptadecanoic acid, decay-corrected to the end of bombardment, was 13% ± 6.3%.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 31759313: 'Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate and methyl 16-bromo-4-thia-palmitate were used as precursors for the synthesis of [18F]FTHA and [18F]FTP, respectively.'.