Tracers / [18F]FTHA
[18F]FTHA
Also written as [18F]fluoro-6-thia-heptadecanoic; [18F]FTHA; [F-18]fluoro-6-thia-heptadecanoic; [F-18]FTHA
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- fluorinated thia fatty acid analog (radiolabeled fatty acid, tosylate-derived thia-heptadecanoate precursor)
- Target / mechanism
- —
- Clinical application
- Imaging of fatty acid circulation/lipid metabolism by PET PMID 38543104
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX N Pro | — | HPLC+SPE | 10.9±2.2 % no | <93.5 % | benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate ABX | 31759313 2020 Nucl Med Biol All the syntheses were optimized in an automated TRACERlab FX-N Pro synthesizer. — for [18F]FTHA the uncorrected yield was 10.9±2.2 % |
| — | fixed tubing | HPLC+SPE | 5.52 ± 2.38% | >95% | Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate | 38543104 2024 Pharmaceuticals (Basel) a former 11C-methylation vessel-based PET synthesizer (formerly Nuclear Interface, now General Electric Medical Systems, Uppsala, Sweden) was used. — a radiochemical yield (RCY) of 5.52 ± 2.38% (0.23–4.56 GBq) at the end of the synthesis (EOS) |
| ELIXYS FLEX/CHEM Sofie Biosciences | vendor cassette | HPLC+SPE | 13.01 ± 5.63% | >95% | Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate | 38543104 2024 Pharmaceuticals (Basel) Radiochemical production was performed on the Elixys Flex/Chem (Sofie Biosciences, Dulles, VA, USA), a commercially available automated disposable cassette-based radiosynthesizer. Purification and formulation were performed on the commercially available automated unit, Pure/Form (Sofie Biosciences). — a significantly increased RCY of 13.01 ± 5.63% (1.60–6.27 GBq) at the EOS starting from 19–26 GBq (Table 1) |
| — | — | HPLC+SPE | 13% ± 6.3% yes | — | — | 29205456 2018 J Labelled Comp Radiopharm An automated synthesis device was constructed in-house for multistep nucleophilic 18 F-fluorination and a control system was developed. — The radiochemical yield of 14-(R,S)-[18 F]fluoro-6-thia-heptadecanoic acid, decay-corrected to the end of bombardment, was 13% ± 6.3%. |
Need this precursor?We can point you to suppliers for [18F]FTHA, or handle the enquiry for you.
Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FTHA.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 31759313: 'Benzyl-14-(R,S)-tosyloxy-6-thiaheptadecanoate and methyl 16-bromo-4-thia-palmitate were used as precursors for the synthesis of [18F]FTHA and [18F]FTP, respectively.'.