Tracer library / [18F]FTC-146
Structure of FTC-146 (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 58511957

[18F]FTC-146

Also written as [18F]FTC-146; [F-18]FTC-146
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
Clinical research
Syntheses indexed
0

What it is

Compound class
sigma-1 receptor PET radioligand
Target / mechanism
sigma-1 receptor (S1R) PMID 30349360
Clinical application
Complex regional pain syndrome (CRPS) PMID 41557146
Theranostic pair
—

Published syntheses

No synthesis has been parsed for this agent yet.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146.
    2017 · Mol Imaging Biol · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) neu-pain from consolidated missing-rubric review. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.
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