Tracers / [18F]FTC-146

[18F]FTC-146

Also written as [18F]FTC-146; [F-18]FTC-146
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
first-in-human
Syntheses indexed
1
Inflammatory diseaseChronic / neuropathic pain imaging

What it is

Compound class
sigma-1 receptor PET radioligand
Target / mechanism
sigma-1 receptor (S1R) PMID 30349360
Clinical application
Complex regional pain syndrome (CRPS) PMID 41557146
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
———3.3 ± 0.7 %
yes
>95 %—28280965
2017 Mol Imaging Biol
A reliable and automated radiosynthesis for providing routine clinical-grade [18F]FTC-146 for human studies was established in a modified GE TRACERlab FXFN. — [18F]FTC-146 was synthesized with a radiochemical yield of 3.3 ± 0.7 % and specific radioactivity of 8.3 ± 3.3 Ci/μmol (n = 10, decay corrected to EOB).

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) neu-pain from consolidated missing-rubric review.