Tracer library / [18F]FMPEP-d2
Structure of FMPEP-d2 (isotope-labelled compound, from PubChem)
Isotope-labelled compoundPubChem CID 169493194

[18F]FMPEP-d2

Also written as [18F]FMPEP-d2; [F-18]FMPEP-d2
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
CNS receptor and transporter imaging

What it is

Compound class
Cannabinoid CB1 receptor PET tracer (fluoroalkylated pyrrolidinone derivative)
Target / mechanism
CB1R inverse agonist PMID 37736496
Clinical application
Neurodegenerative disorders associated with abnormalities in regional CB1R density PMID 37736496
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Synthra RNplus—————37736496
2023 Am J Nucl Med Mol Imaging
fully automated radiosynthesis of [18F]FMPEP-d2 on a Synthra RNplus research module
In-house / custom built
Laboratory
—HPLC———32374481
2020 J Labelled Comp Radiopharm
we describe the development of an in-house-built device for the fully automated multistep synthesis

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with F-18.
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