Tracer library / [18F]FMAU
[18F]FMAU
Also written as [18F]FMAU; [F-18]FMAU; FMAU
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- Radiolabelled pyrimidine nucleoside analogue (arabinofuranosyl-uracil derivative)
- Target / mechanism
- Thymidine kinase-mediated phosphorylation and incorporation into DNA (marker of DNA synthesis) PMID 12468521
- Clinical application
- monitoring cellular proliferation via PET imaging PMID 21315275
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| In-house / custom built | custom manifold | HPLC+SPE | 28±7% decay-corrected | — | uracil precursor | 23702795 2013 Appl Radiat Isot 1-(2′-deoxy-2′-[18F]fluoro-β-D-arabinofuranosyl)thymine (D-[18F]FMAU) was also synthesized on the system using the same protocol as for D-[18F]FAC - with a decay-corrected radiochemical yield of 28±7% (n=3) |
| ELIXYS FLEX/CHEM Sofie | vendor cassette | HPLC | 46 ± 1 decay-corrected | >99% | 2-O-(trifluoromethylsulfonyl)-1,3,5-tri-O-be…2-O-(trifluoromethylsulfonyl)-1,3,5-tri-O-benzoyl-alpha-l-ribo-furanose and 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine ABX | 23849185 2013 EJNMMI Res an automated three-reactor radiosynthesizer (ELIXYS) - 46% ± 1% (n = 6) and 31% ± 5% (n = 6), respectively |
| — | — | HPLC | 20 ± 4% decay-corrected | >99% | 2-deoxy-2-[(18)F]fluoro-1,3,5-tri-O-benzoyl-…2-deoxy-2-[(18)F]fluoro-1,3,5-tri-O-benzoyl-d-arabinofuranose | 22503457 2012 Nucl Med Biol Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU). - The overall radiochemical yield was 20 ± 4% (decay corrected, n=3). |
| — | — | HPLC | 12±3% decay-corrected | >99% | — | 21315275 2011 Nucl Med Biol a fully automated synthesis of [(18)F]-FMAU based on a one reactor radiosynthesis module - [(18)F]-FMAU was obtained in 12±3% radiochemical yield (decay corrected overall yield based on [(18)F]-F(-), n=4) |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FMAU.
Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with F-18.