Tracers / [18F]fluoromethyl tosylate

[18F]fluoromethyl tosylate

Also written as [18F]fluoromethyl tosylate

Radionuclide: F-18 t½ 109.7 min
Modality: n/a
Production route: Cyclotron liquid target
Stage: n/a
Syntheses indexed: 0

Radiochemistry methodology

What it is

Compound class: Prosthetic group / synthon
Target / mechanism: n/a
Clinical application: n/a
Theranostic pair: —

Regulatory status

FDA: No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=fluoromethyl+tosylate
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor: Ditosylmethane (bis(toluenesulfonyloxy)methane); [18F]fluoride displaces one tosylate to give [18F]fluoromethyl tosylate PMID 23665261 / DOI 10.1016/j.apradiso.2013.04.017
Suppliers seen in the literature: ABX Advanced Biochemicals (Radeberg, Germany), or prepared in-house (from diiodomethane and AgOTs)
Typical final purification: HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Synthon, not a tracer. Keep out of the main tracer list on the site.