Tracer library / [18F]fluoroethylcholine
[18F]fluoroethylcholine
Also written as [18F]fluoroethylcholine; [F-18]fluoroethylcholine; Fluoroethylcholine
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
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- Syntheses indexed
- 11
What it is
- Compound class
- radiolabeled choline analogue
- Target / mechanism
- —
- Clinical application
- Prostate cancer PET imaging PMID 18819809
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX FN GE HealthCare | custom manifold | SPE | 5% not corrected | — | dibromomethane Sigma-Aldrich | 21769163 2011 J Labelled Comp Radiopharm The TracerLab FXFN was configured as shown in Figure 11 - Typical non-decay corrected yields of [18F]fluoromethylcholine using this optimized production method were 5%, (n = 7). |
| TRACERlab FX2 C GE HealthCare | — | SPE | 8 ± 3% | 97.3 ± 2.6% | dimethylaminoethanol precursor | 33153893 2021 Appl Radiat Isot We have used FX2C and FX2N Tracerlab modules for the synthesis of the [11C]methionine, [18F]choline and [18F]fluorodopa via nucleophilic pathway in FX2C/N module. - [18F]fluoromethylcholine was prepared with high radiochemical purity of 97.3 ± 2.6% with yield of 8 ± 3%. |
| Modular-Lab (model not stated) Eckert & Ziegler | — | SPE | 36% not corrected | — | ethyleneglycolditosylate | 19520298 2009 Nucl Med Biol We used a Modular Lab system to automatically perform the two-step/one-pot synthesis. - The optimized procedure resulted in a non decay corrected yield of 36% |
| TRACERlab MX GE HealthCare | — | SPE | 15-25% not corrected | >99% | N,N-dimethylaminoethanol | 18312837 2008 Nucl Med Biol Fully automated [18F]fluorocholine synthesis in the TracerLab MX FDG Coincidence synthesizer. - the [18F]fluorocholine was obtained in 15-25% radiochemical yields (decay not corrected) |
| FASTlab 2 GE HealthCare | — | SPE | 17.8 ± 2.5 % | >99 % | Dibromomethane (DBM) | 40147115 2025 Appl Radiat Isot synthesis, purification and formulation of [18F]FCH on the GE FASTlab II utilizing a single-use cassette was reported. - the radiochemical yield of [18F]FCH was 17.8 ± 2.5 % |
| TRACERlab FX FN GE HealthCare | — | SPE | 18.8 ± 2.1% | >90% | dibromomethane | 28734194 2017 Appl Radiat Isot [18F]FCH was synthesized using a modified TRACERlab FxFN module. - the RCY of [18F]FCH was 18.8 ± 2.1% (EOB, n = 27) |
| TRACERlab FX FN GE HealthCare | — | SPE | 4-6% | >99.7% | — | 21115355 2011 Appl Radiat Isot modification of a GE TracerLab FX(FN) is reported which enables gas-phase production of [(18)F]fluoromethylcholine - in 4-6% RCY and >99.7% RCP |
| Raytest SynChrom Elysia-Raytest | — | SPE | 37±5% | >95% | 2-bromoethyl-4-nitrobenzenesulfonate (BENos) | 21315271 2011 Nucl Med Biol The fully automated synthesis was performed using as well a Raytest SynChrom module (Raytest, Germany) or a Scintomics HotboxIII module (Scintomics, Germany). - 37±5% (Synchrom module) |
| Scintomics HotBox III Scintomics | — | SPE | 33±5% | >95% | 2-bromoethyl-4-nitrobenzenesulfonate (BENos) | 21315271 2011 Nucl Med Biol The fully automated synthesis was performed using as well a Raytest SynChrom module (Raytest, Germany) or a Scintomics HotboxIII module (Scintomics, Germany). - 33±5% (Hotbox III unit) |
| — | — | SPE | 47±5% not corrected | >99.9% | 2-bromoethyl triflate (BETfO) | 18819809 2008 Bioorg Med Chem a modified, commercially available fully automated synthesis module - resulting in a total yield of 47+/-5% (not decay corrected) in only 40min |
| — | — | — | 30±6% | 95-99% | N,N-dimethylaminoethanol | 17346977 2007 Bioorg Med Chem we established a reliable, fully automated synthesis for its production using a modified, commercially available module - resulting in a total radiochemical yield of 30+/-6% after a synthesis time of 50 min |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
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- Cited suppliers in indexed syntheses
- Sigma-Aldrich
- Typical final purification
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic solvent confirmed in synthesis data (PMID 21769163) -> GC residual solvents; conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluoroethylcholine.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.